Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 4/20 | 0.55 |
| ▸ | HTR2C | P28335 | 4/20 | 0.55 |
| ▸ | HTR2B | P41595 | 4/20 | 0.55 |
| ▸ | PBRM1 | Q86U86 | 7/20 | 0.45 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | BACE1 | P56817 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12714643 | 0.83 | HTR2A (0.40) | HTR2AHTR2CHTR2BPBRM1MKNK1 | |
| SCHEMBL31159197 | 0.79 | PBRM1 (0.44) | HTR2AHTR2CHTR2BPBRM1TNKS2 | |
| SCHEMBL19358233 | 0.79 | PBRM1 (0.51) | HTR2AHTR2CHTR2BPBRM1MKNK1 | |
| SCHEMBL11358726 | 0.79 | HTR2A (0.54) | HTR2AHTR2CHTR2BPBRM1ALDH1A1 | |
| SCHEMBL30451265 | 0.78 | HTR2C (0.56) | HTR2AHTR2CHTR2BPBRM1ALDH1A1 | |
| SCHEMBL29010215 | 0.77 | HTR2A (0.51) | HTR2AHTR2CHTR2BPBRM1ALDH1A1 | |
| SCHEMBL22225436 | 0.77 | ROCK2 (0.37) | HTR2AHTR2CHTR2BPBRM1CYP1A2 | |
| SCHEMBL12718314 | 0.77 | HTR2A (0.51) | HTR2AHTR2CHTR2BPBRM1ALDH1A1 | |
| SCHEMBL13802283 | 0.75 | CREBBP (0.56) | HTR2AHTR2CHTR2BPBRM1GSK3B | |
| SCHEMBL13802289 | 0.75 | CREBBP (0.56) | HTR2AHTR2CHTR2BPBRM1GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110086842-A1 | Pyrimidines as PLK inhibitors | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2011-04-14 | — | — | US | disclosed |
| US-20090163465-A1 | Pyrimidines as PLK inhibitors | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-06-25 | — | — | US | disclosed |
| US-20090149438-A1 | Pyrimidines as PLK inhibitors | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-06-11 | — | — | US | disclosed |
| US-7521457-B2 | Pyrimidines as PLK inhibitors | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-04-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090163465-A1 | Pyrimidines as PLK inhibitors | PLK2, PLK3, TYMP | HTR2A 3341/4885HTR2C 3994/4885HTR2B 3945/4885 |
| US-20110086842-A1 | Pyrimidines as PLK inhibitors | PLK2, PLK3, TYMP | HTR2A 3341/4885HTR2C 3994/4885HTR2B 3945/4885 |
| US-20090149438-A1 | Pyrimidines as PLK inhibitors | PLK2, PLK3, TYMP | HTR2A 3341/4885HTR2C 3994/4885HTR2B 3945/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.