SCHEMBL1272199

SCHEMBL1272199

NC(=O)CCC(N)C(=O)NC(=O)CCNC(=O)[C@@H](N)Cc1c[nH]c2ccccc12

nearest known ligand 0.53

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
CTSC P53634 2/20 0.53
KDM4E B2RXH2 1/20 0.52
MEN1 O00255 1/20 0.52
LMNA P02545 1/20 0.52
MPO P05164 1/20 0.52
MAPT P10636 1/20 0.52
TSHR P16473 1/20 0.52
BLM P54132 1/20 0.52
PMP22 Q01453 1/20 0.52
KMT2A Q03164 1/20 0.52
HIF1A Q16665 1/20 0.52
HDAC8 Q9BY41 1/20 0.52
NLN Q9BYT8 1/20 0.51
ACHE P22303 10/20 0.48
BCHE P06276 9/20 0.48
KRAS P01116 1/20 0.46
SOS1 Q07889 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1270426 0.91 KDM4E (0.53) CTSCKDM4EMEN1LMNAMPO
SCHEMBL1132875 0.84 CTSC (0.72) CTSCKDM4EMEN1LMNAMAPT
SCHEMBL1271407 0.84 CTSL (0.61) MAPTACHEBCHE
SCHEMBL1270414 0.80 CTSC (0.51) CTSCKDM4EMEN1LMNAMPO
Hydrochloric Acid SCHEMBL21082953 0.79 KDM4E (0.65) CTSCKDM4EMEN1LMNAMPO
Hydrochloric Acid SCHEMBL21082950 0.79 KDM4E (0.65) CTSCKDM4EMEN1LMNAMPO
SCHEMBL1132348 0.79 KDM4E (0.65) KDM4EMEN1LMNAMPOMAPT
Hydrochloric Acid SCHEMBL21082951 0.79 KDM4E (0.65) CTSCKDM4EMEN1LMNAMPO
Hydrochloric Acid SCHEMBL21082974 0.79 KDM4E (0.65) CTSCKDM4EMEN1LMNAMPO
SCHEMBL19835901 0.79 KDM4E (0.65) CTSCKDM4EMEN1LMNAMPO

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20110038885-A1 CHEMOKINE ANALOGS IPSEN PHARMA S.A.S. (FR) 2011-02-17 US claimed
US-20110038885-A1 CHEMOKINE ANALOGS IPSEN PHARMA S.A.S. (FR) 2011-02-17 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110038885-A1 CHEMOKINE ANALOGS CCL11, CCL5, CCL2 CTSC 169/4885KDM4E 4825/4885MEN1 2251/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.