SCHEMBL12733162

SCHEMBL12733162

O=C1c2ccccc2C(=O)N1c1cc(O)c(N2C(=O)c3ccccc3C2=O)cc1O

nearest known ligand 0.51

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
ESR1 P03372 3/20 0.51
ESR2 Q92731 2/20 0.51
NR1H3 Q13133 5/20 0.51
SCN2A Q99250 2/20 0.50
POLB P06746 1/20 0.50
PIM3 Q86V86 1/20 0.50
HIPK4 Q8NE63 1/20 0.50
CYP3A4 P08684 1/20 0.49
NFKB1 P19838 1/20 0.49
PMP22 Q01453 1/20 0.49
TYMS P04818 1/20 0.48
ALDH1A1 P00352 1/20 0.46
NR1H2 P55055 2/20 0.45
BCL2 P10415 1/20 0.45
MCL1 Q07820 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6005895 0.84 ESR1 (0.62) ESR1ESR2NR1H3SCN2APIM3
SCHEMBL5352001 0.83 SCN2A (0.64) ESR1ESR2NR1H3SCN2APIM3
SCHEMBL2150841 0.83 MEN1 (0.55) ESR1ESR2NR1H3SCN2APOLB
SCHEMBL19950447 0.81 CYP3A4 (0.61) ESR1ESR2NR1H3SCN2APOLB
SCHEMBL7514060 0.81 MEN1 (0.49) ESR1ESR2NR1H3SCN2APIM3
SCHEMBL9240516 0.81 CYP3A4 (0.66) ESR1ESR2NR1H3SCN2APOLB
SCHEMBL30268221 0.80 TYMS (0.72) ESR1ESR2NR1H3SCN2APIM3
Hydrochloric Acid SCHEMBL29690161 0.80 CYP3A4 (0.64) ESR1ESR2NR1H3SCN2APOLB
SCHEMBL4649466 0.79 POLB (0.65) NR1H3POLBCYP3A4NFKB1PMP22
SCHEMBL12462986 0.78 NR1H3 (0.37) ESR1ESR2NR1H3SCN2APOLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7919219-B2 Electrophotographic photosensitive body HODOGAYA CHEMICAL CO., LTD. (JP) 2011-04-05 US disclosed
US-7534539-B2 Electrophotographic photoreceptor and image forming apparatus having the same SHARP KABUSHIKI KAISHA (JP) 2009-05-19 US disclosed
US-7534539-B2 Electrophotographic photoreceptor and image forming apparatus having the same SHARP KABUSHIKI KAISHA (JP) 2009-05-19 US disclosed
US-20080044750-A1 Electrophotographic Photosensitive Body HODOGAYA CHEMICAL CO., LTD. (JP) 2008-02-21 US disclosed
US-7314693-B2 Electrophotographic photoconductor, electrophotographic process, electrophotographic apparatus, and process cartridge RICOH COMPANY, LTD. (JP) 2008-01-01 US disclosed
EP-1818725-A1 ELECTROPHOTOGRAPHIC PHOTOSENSITIVE BODY Hodogaya Chemical Co., Ltd. (JP) 2007-08-15 EP disclosed