Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYMS | P04818 | 1/20 | 0.72 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.48 |
| ▸ | NR1H3 | Q13133 | 3/20 | 0.47 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.47 |
| ▸ | ESR1 | P03372 | 2/20 | 0.47 |
| ▸ | ACMSD | Q8TDX5 | 2/20 | 0.46 |
| ▸ | DHFR | P00374 | 1/20 | 0.46 |
| ▸ | HNF4A | P41235 | 1/20 | 0.46 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.46 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.45 |
| ▸ | HIPK4 | Q8NE63 | 1/20 | 0.45 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 3/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21857580 | 0.86 | ALDH1A1 (0.71) | TYMSALDH1A1HSD17B10MEN1KMT2A | |
| SCHEMBL23752283 | 0.85 | TYMS (1.00) | TYMSMEN1LMNAKMT2A | |
| SCHEMBL6005895 | 0.81 | ESR1 (0.62) | TYMSNR1H3ESR2ESR1PIM3 | |
| SCHEMBL21953468 | 0.81 | EGFR (0.60) | TYMSALDH1A1HSD17B10ATMSMN1; SMN2 | |
| SCHEMBL30268541 | 0.81 | EGFR (0.60) | TYMSALDH1A1HSD17B10ATMSMN1; SMN2 | |
| SCHEMBL12733162 | 0.80 | ESR1 (0.51) | TYMSALDH1A1NR1H3ESR2ESR1 | |
| SCHEMBL19950447 | 0.78 | CYP3A4 (0.61) | TYMSALDH1A1NR1H3ESR2ESR1 | |
| SCHEMBL27859806 | 0.77 | SCN2A (0.59) | TYMSALDH1A1NR1H3SCN2AHTT | |
| SCHEMBL9067222 | 0.76 | MGLL (0.68) | TYMSALDH1A1NR1H3HTTHSD17B10 | |
| SCHEMBL2150841 | 0.76 | MEN1 (0.55) | ALDH1A1NR1H3ESR2ESR1PIM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230047816-A1 | PFKFB3 INHIBITORS AND THEIR USES | GERO PTE. LTD. (SG) | 2023-02-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230047816-A1 | PFKFB3 INHIBITORS AND THEIR USES | PFKFB3, PFKFB4, PFKFB1 | TYMS 1009/4885ALDH1A1 1943/4885ALOX5 1876/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.