2',4'-Dihydroxychalcone

2',4'-Dihydroxychalcone

SCHEMBL127341

O=C(C=Cc1ccccc1)c1ccc(O)cc1O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 6/20 1.00
CYP3A4 P08684 5/20 1.00
MEN1 O00255 5/20 1.00
KMT2A Q03164 5/20 1.00
HPGD P15428 4/20 1.00
ALOX15 P16050 4/20 1.00
MAPK1 P28482 4/20 1.00
HSD17B10 Q99714 3/20 1.00
TDP1 Q9NUW8 3/20 1.00
ALDH1A1 P00352 3/20 1.00
KDM4E B2RXH2 2/20 1.00
SMN1; SMN2 Q16637 2/20 1.00
THRB P10828 1/20 1.00
CYP2C19 P33261 3/20 0.81
NFKB1 P19838 3/20 0.81
LMNA P02545 3/20 0.81
TP53 P04637 3/20 0.81
CYP2C9 P11712 2/20 0.81
AKR1B1 P15121 2/20 0.81
CHRNA7 P36544 2/20 0.81

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
2',4'-Dihydroxychalcone SCHEMBL1411695 1.00 MAPT (1.00) MAPTCYP3A4MEN1KMT2AHPGD
2',4'-Dihydroxychalcone SCHEMBL25200440 1.00 MAPT (1.00) MAPTCYP3A4MEN1KMT2AHPGD
Isoliquiritigenin SCHEMBL9448612 0.93 CYP3A4 (0.86) MAPTCYP3A4MEN1KMT2AHPGD
Isoliquiritigenin SCHEMBL9448617 0.93 CYP3A4 (0.86) MAPTCYP3A4MEN1KMT2AHPGD
SCHEMBL25208375 0.91 MEN1 (0.96) MAPTCYP3A4MEN1KMT2AHPGD
Isoliquiritigenin SCHEMBL1519061 0.91 CYP3A4 (0.83) MAPTCYP3A4MEN1KMT2AHPGD
SCHEMBL25194934 0.91 CYP3A4 (0.83) MAPTCYP3A4MEN1KMT2AHPGD
SCHEMBL25195193 0.90 MEN1 (0.82) MAPTCYP3A4MEN1KMT2AHPGD
SCHEMBL28093997 0.90 MEN1 (0.82) MAPTCYP3A4MEN1KMT2AHPGD
Isoliquiritigenin SCHEMBL10408923 0.90 CYP3A4 (1.00) MAPTCYP3A4MEN1KMT2AHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 396 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260096569-A1 EDIBLE COATING WITH ANTIMICROBIAL PROPERTIES APEEL TECH INC (US) 2026-04-09 US claimed
US-20260060940-A1 NUCLEOTIDE-BINDING DOMAIN AND LEUCINE-RICH REPEAT PROTEIN 3 INFLAMMASOME INHIBITOR FOR TREATING INFLAMMATORY INTESTINAL DISEASES UNIV MACAU (CN) 2026-03-05 US claimed
EP-4496476-A1 GAS PHASE TREATMENT OF PRODUCE Apeel Technology, Inc. (US) 2025-01-29 EP claimed
US-20240373850-A1 Compositions comprising resinous exudate metabolites from plants of the genus Adesmia, used to control and treat infections in plant crops; and methods for controlling infections in plant crops. PONTIFICIA UNIV CATOLICA DE VALPARAISO (CL) 2024-11-14 US claimed
CN-117320559-A Edible coating with antimicrobial properties 阿比尔技术公司 2023-12-29 CN claimed
WO-2023183341-A1 GAS PHASE TREATMENT OF PRODUCE APEEL TECHNOLOGY, INC. (US) 2023-09-28 WO claimed
US-20230003721-A1 MITOTHERAPEUTICS FOR THE TREATMENT OF BRAIN DISORDERS THE UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. 2023-01-05 US claimed
WO-2022221968-A1 COMPOSITIONS COMPRISING RESINOUS EXUDATE METABOLITES FROM PLANTS OF THE GENUS ADESMIA, USED TO CONTROL AND TREAT INFECTIONS IN PLANT CROPS; AND METHODS FOR CONTROLLING INFECTIONS IN PLANT CROPS PONTIFICIA UNIVERSIDAD CATÓLICA DE VALPARAÍSO (CL) 2022-10-27 WO claimed
US-20220330565-A1 EDIBLE COATING WITH ANTIMICROBIAL PROPERTIES APEEL TECHNOLOGY, INC. 2022-10-20 US claimed
US-10314811-B2 Compositions and methods for selectively inhibiting intestinal carboxylesterase 2 enzyme activity THE METHODIST HOSPITAL (US) 2019-06-11 US claimed
US-20180235928-A1 COMPOSITIONS AND METHODS FOR SELECTIVELY INHIBITING INTESTINAL CARBOXYLESTERASE 2 ENZYME ACTIVITY METHODIST HOSPITAL (US) 2018-08-23 US claimed
EP-3337563-A1 COMPOSITIONS AND METHODS FOR SELECTIVELY INHIBITING INTESTINAL CARBOXYLESTERASE 2 ENZYME ACTIVITY The Methodist Hospital (US) 2018-06-27 EP claimed
WO-2017034919-A1 COMPOSITIONS AND METHODS FOR SELECTIVELY INHIBITING INTESTINAL CARBOXYLESTERASE 2 ENZYME ACTIVITY THE METHODIST HOSPITAL (US) 2017-03-02 WO claimed
EP-0800387-B1 CHALCONES AND ESTERS THEREOF WITH ANTIPROLIFERATIVE ACTIVITY IN UTERUS, OVARY AND BREAST TUMOURS INDENA SPA (IT) 2002-08-28 EP claimed
US-5808137-A Chalcones and esters thereof with antiproliferative activity in uterus, ovary and breast tumors INDENA S.P.A. (IT) 1998-09-15 US claimed
EP-0800387-A1 CHALCONES AND ESTERS THEREOF WITH ANTIPROLIFERATIVE ACTIVITY IN UTERUS, OVARY AND BREAST TUMOURS INDENA S.p.A. (IT) 1997-10-15 EP claimed
WO-1996019209-A1 CHALCONES AND ESTERS THEREOF WITH ANTIPROLIFERATIVE ACTIVITY IN UTERUS, OVARY AND BREAST TUMOURS INDENA S.P.A. (IT) 1996-06-27 WO claimed
US-20260096569-A1 EDIBLE COATING WITH ANTIMICROBIAL PROPERTIES APEEL TECH INC (US) 2026-04-09 US disclosed
EP-0502205-A1 CHALCONE DERIVATIVE AND ULTRAVIOLET SCREENING COSMETIC NIPPON HYPOX LABORATORIES INCORPORATED (JP) 1992-09-09 EP disclosed
US-4111907-A PHOTOPOLYMERIZABLE KETONES CIBA-GEIGY CORPORATION (US) 1978-09-05 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260060940-A1 NUCLEOTIDE-BINDING DOMAIN AND LEUCINE-RICH REPEAT PROTEIN 3 INFLAMMASOME INHIBITOR FOR TREATING INFLAMMATORY INTESTINAL DISEASES NLRP3, NLRP1, NOD1 MAPT 926/4885CYP3A4 914/4885MEN1 4828/4885
US-20240373850-A1 Compositions comprising resinous exudate metabolites from plants of the genus Adesmia, used to control and treat infections in plant crops; and methods for controlling infections in plant crops. ERG28, RXFP4, CROCC MAPT 4500/4885CYP3A4 1006/4885MEN1 2124/4885
US-20260096569-A1 EDIBLE COATING WITH ANTIMICROBIAL PROPERTIES CYP51A1, ERG28, NISCH MAPT 4702/4885CYP3A4 3888/4885MEN1 1914/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.