Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 2/20 | 0.60 |
| ▸ | TRPC3 | Q13507 | 1/20 | 0.54 |
| ▸ | TRPC6 | Q9Y210 | 1/20 | 0.54 |
| ▸ | SCN9A | Q15858 | 4/20 | 0.53 |
| ▸ | HPGD | P15428 | 4/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | CRHBP | P24387 | 1/20 | 0.46 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12753370 | 0.88 | HSD11B1 (0.57) | HSD11B1TRPC3TRPC6HPGDALDH1A1 | |
| SCHEMBL12753346 | 0.88 | HSD11B1 (0.60) | HSD11B1SCN9AHPGDALDH1A1KDM4E | |
| SCHEMBL12753347 | 0.86 | HSD11B1 (0.67) | HSD11B1SCN9AHPGDALDH1A1KDM4E | |
| SCHEMBL12753329 | 0.86 | HSD11B1 (0.63) | HSD11B1TRPC3TRPC6SCN9AHPGD | |
| SCHEMBL12753443 | 0.86 | SCN9A (0.59) | HSD11B1SCN9AHPGDALDH1A1KDM4E | |
| SCHEMBL12753656 | 0.86 | HSD11B1 (0.70) | HSD11B1SCN9AHPGDALDH1A1KDM4E | |
| SCHEMBL12754306 | 0.85 | HSD11B1 (0.54) | HSD11B1SCN9AHPGDALDH1A1KDM4E | |
| SCHEMBL12753324 | 0.85 | HSD11B1 (0.62) | HSD11B1SCN9AHPGDALDH1A1KDM4E | |
| SCHEMBL12753327 | 0.85 | HSD11B1 (0.69) | HSD11B1TRPC3TRPC6SCN9AHPGD | |
| SCHEMBL12753509 | 0.85 | HSD11B1 (0.56) | HSD11B1TRPC3TRPC6SCN9AHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110077395-A1 | INHIBITORS OF 11-BETA HYDROXYSTEROID DEHYDROGENASE TYPE I | BRISTOL-MYERS SQUIBB COMPANY | 2011-03-31 | — | — | US | disclosed |
| US-20110077395-A1 | INHIBITORS OF 11-BETA HYDROXYSTEROID DEHYDROGENASE TYPE I | BRISTOL-MYERS SQUIBB COMPANY | 2011-03-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110077395-A1 | INHIBITORS OF 11-BETA HYDROXYSTEROID DEHYDROGENASE TYPE I | HSD11B1, HSD3B1, HSD17B1 | HSD11B1 1/4885TRPC3 4874/4885TRPC6 4876/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.