Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 11/20 | 0.62 |
| ▸ | PTPN2 | P17706 | 7/20 | 0.62 |
| ▸ | F3 | P13726 | 3/20 | 0.62 |
| ▸ | PNLIP | P16233 | 1/20 | 0.62 |
| ▸ | NOS2 | P35228 | 1/20 | 0.62 |
| ▸ | POLB | P06746 | 3/20 | 0.60 |
| ▸ | AKR1B10 | O60218 | 3/20 | 0.60 |
| ▸ | GPBAR1 | Q8TDU6 | 3/20 | 0.60 |
| ▸ | PSMB11 | A5LHX3 | 2/20 | 0.60 |
| ▸ | PSMA7 | O14818 | 2/20 | 0.60 |
| ▸ | PLA2G1B | P04054 | 2/20 | 0.60 |
| ▸ | PTPRC | P08575 | 2/20 | 0.60 |
| ▸ | PTPRF | P10586 | 2/20 | 0.60 |
| ▸ | PSMB1 | P20618 | 2/20 | 0.60 |
| ▸ | CES1 | P23141 | 2/20 | 0.60 |
| ▸ | ACP1 | P24666 | 2/20 | 0.60 |
| ▸ | PSMA1 | P25786 | 2/20 | 0.60 |
| ▸ | PSMA2 | P25787 | 2/20 | 0.60 |
| ▸ | PSMA3 | P25788 | 2/20 | 0.60 |
| ▸ | PSMA4 | P25789 | 2/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5799296 | 0.81 | PTPN1 (0.73) | PTPN1PTPN2F3PNLIPNOS2 | |
| SCHEMBL2586364 | 0.81 | PTPN1 (0.73) | PTPN1PTPN2F3PNLIPNOS2 | |
| SCHEMBL381229 | 0.79 | PTPN1 (0.69) | PTPN1PTPN2F3PNLIPNOS2 | |
| Oleanonic Acid SCHEMBL6898284 | 0.77 | PTPN2 (1.00) | PTPN1PTPN2F3PNLIPNOS2 | |
| Oleanonic Acid SCHEMBL12313105 | 0.77 | PTPN2 (1.00) | PTPN1PTPN2F3PNLIPNOS2 | |
| Oleanonic Acid SCHEMBL18687844 | 0.77 | PTPN2 (1.00) | PTPN1PTPN2F3PNLIPNOS2 | |
| Oleanonic Acid SCHEMBL18688313 | 0.77 | PTPN2 (1.00) | PTPN1PTPN2F3PNLIPNOS2 | |
| Oleanonic Acid SCHEMBL246220 | 0.77 | PTPN2 (1.00) | PTPN1PTPN2F3PNLIPNOS2 | |
| Oleanonic Acid SCHEMBL12200334 | 0.77 | PTPN2 (1.00) | PTPN1PTPN2F3PNLIPNOS2 | |
| Oleanonic Acid SCHEMBL12337276 | 0.77 | PTPN2 (1.00) | PTPN1PTPN2F3PNLIPNOS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8318425-B2 | Inhibition of HIV-1 replication by disruption of the processing of the viral capsid-spacer peptide 1 protein | The United States of America, as represented by the Secretary, Department & Human Services (US) | 2012-11-27 | — | — | US | disclosed |
| US-20120214775-A1 | Pharmaceutical Salts of 3-O-(3',3'-Dimethylsuccinyl) Betulinic Acid | MYREXIS, INC. (US) | 2012-08-23 | — | — | US | disclosed |
| EP-1868613-B1 | POLYMORPHS OF 3-O-(3',3'-DIMETHYLSUCCINYL) BETULINIC ACID DI-N-METHYL-D-GLUCAMINE | MYREXIS INC (US) | 2012-03-07 | — | — | EP | disclosed |
| US-7799768-B2 | Polymorphs of 3-O-(3′,3′-dimethylsuccinyl)betulinic acid di-N-methyl-D-glucamine | MYREXIS, INC. (US) | 2010-09-21 | — | — | US | disclosed |
| US-20100221264-A1 | Inhibition of HIV-1 Replication by Disruption of the Processing of the Viral Capsid-Spacer Peptide 1 Protein | PANACOS PHARMACEUTICALS, INC. (US) | 2010-09-02 | — | — | US | disclosed |
| EP-1758640-A4 | INHIBITION OF HIV-1 REPLICATION BY DISRUPTION OF THE PROCESSING OF THE VIRAL CAPSID-SPACER PEPTIDE 1 PROTEIN | PANACOS PHARMACEUTICALS INC (US) | 2009-06-03 | — | — | EP | disclosed |
| US-7537765-B2 | Inhibition of HIV-1 replication by disruption of the processing of the viral capsid-spacer peptide 1 protein | PANACOS PHARMACEUTICALS, INC. (US) | 2009-05-26 | — | — | US | disclosed |
| US-20080233559-A1 | Inhibition of HIV-1 Replication by Disruption of the Processing of the Viral Capsid-Spacer Peptide 1 Protein | PANACOS PHARMACEUTICALS, INC. | 2008-09-25 | — | — | US | disclosed |
| US-20080200550-A1 | Inhibition of Hiv-1 Replication by Disruption of the Processing of the Viral Capsid-Spacer Peptide 1 Protein | V.I. TECHNOLOGIES, INC. (US) | 2008-08-21 | — | — | US | disclosed |
| EP-1868613-A4 | POLYMORPHS OF 3-O-(3',3'-DIMETHYLSUCCINYL) BETULINIC ACID DI-N-METHYL-D-GLUCAMINE | PANACOS PHARMACEUTICALS INC (US) | 2008-04-30 | — | — | EP | disclosed |
| EP-1730163-A1 | PHARMACEUTICALS SALTS OF 3-O-(3,3-DIMETHYLSUCCINYL) BETULINIC ACID | Panacos Pharmaceuticals, Inc. (US) | 2006-12-13 | — | — | EP | disclosed |
| US-20060252704-A1 | Polymorphs of 3-O-(3',3'-dimethylsuccinyl)betulinic acid di-N-methyl-D-glucamine | PANACOS PHARMACEUTICALS, INC. (US) | 2006-11-09 | — | — | US | disclosed |
| WO-2006110810-A2 | POLYMORPHS OF 3-O-(3',3'-DIMETHYLSUCCINYL) BETULINIC ACID DI-N-METHYL-D-GLUCAMINE | PANACOS PHARMACEUTICALS, INC. (US) | 2006-10-19 | — | — | WO | disclosed |
| WO-2005113059-A2 | DISRUPTION OF THE PROCESSING OF THE VIRAL CAPSID-SPACER PEPTIDE 1 PROTEIN | PANACOS PHARMACEUTICALS, INC. (US) | 2005-12-01 | — | — | WO | disclosed |
| EP-1594435-A2 | INHIBITION OF HIV-1 REPLICATION BY DISRUPTION OF THE PROCESSING OF THE VIRAL CAPSID-SPACER PEPTIDE 1 PROTEIN | Salzwedel, Karl (US) | 2005-11-16 | — | — | EP | disclosed |
| US-20050239748-A1 | Pharmaceutical salts of 3-O-(3',3'-dimethylsuccinyl) betulinic acid | PANACOS PHARMACEUTICALS, INC. (US) | 2005-10-27 | — | — | US | disclosed |
| WO-2005090380-A1 | PHARMACEUTICALS SALTS OF 3-O-(3',3'-DIMETHYLSUCCINYL) BETULINIC ACID | PANACOS PHARMACEUTICALS, INC. (US) | 2005-09-29 | — | — | WO | disclosed |
| US-20050015039-A1 | Inhibition of HIV-1 replication by disruption of the processing of the viral capsid-spacer peptide 1 protein | V.I. TECHNOLOGIES, INC. | 2005-01-20 | — | — | US | disclosed |
| US-20040265320-A1 | Inhibition of HIV-1 replication by disruption of the processing of the viral capsid-spacer peptide 1 protein | V.I. TECHNOLOGIES, INC. | 2004-12-30 | — | — | US | disclosed |
| WO-2004069166-A2 | INHIBITION OF HIV-1 REPLICATION BY DISRUPTION OF THE PROCESSING OF THE VIRAL CAPSID-SPACER PEPTIDE 1 PROTEIN | PANACOS PHARMACEUTICALS, INC. (US) | 2004-08-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040265320-A1 | Inhibition of HIV-1 replication by disruption of the processing of the viral capsid-spacer peptide 1 protein | SP1, CPSF1, BET1 | PTPN1 4095/4885PTPN2 4553/4885F3 2191/4885 |
| US-20050239748-A1 | Pharmaceutical salts of 3-O-(3',3'-dimethylsuccinyl) betulinic acid | BET1, OGG1, MPG | PTPN1 4022/4885PTPN2 4435/4885F3 3165/4885 |
| US-20060252704-A1 | Polymorphs of 3-O-(3',3'-dimethylsuccinyl)betulinic acid di-N-methyl-D-glucamine | HLA-DRB1, MPG, OGG1 | PTPN1 2196/4885PTPN2 2341/4885F3 4183/4885 |
| US-20120214775-A1 | Pharmaceutical Salts of 3-O-(3',3'-Dimethylsuccinyl) Betulinic Acid | BET1, OGG1, MPG | PTPN1 4022/4885PTPN2 4435/4885F3 3165/4885 |
| US-20100221264-A1 | Inhibition of HIV-1 Replication by Disruption of the Processing of the Viral Capsid-Spacer Peptide 1 Protein | SP1, CPSF1, BET1 | PTPN1 4095/4885PTPN2 4553/4885F3 2191/4885 |
| US-20080200550-A1 | Inhibition of Hiv-1 Replication by Disruption of the Processing of the Viral Capsid-Spacer Peptide 1 Protein | SP1, CPSF1, SUB1 | PTPN1 4076/4885PTPN2 4528/4885F3 2166/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.