Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 1/20 | 0.52 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.52 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.49 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.49 |
| ▸ | ROCK2 | O75116 | 8/20 | 0.49 |
| ▸ | MAOB | P27338 | 3/20 | 0.48 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.44 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | CDC42BPA | Q5VT25 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12756734 | 0.88 | NPY5R (0.39) | HDAC1HDAC2ROCK1 | |
| SCHEMBL12756749 | 0.85 | TP53 (0.56) | ROCK2ROCK1RPS6KB1TP53CDC42BPA | |
| SCHEMBL12756753 | 0.84 | NFKB1 (0.43) | HDAC1HDAC2 | |
| SCHEMBL12756748 | 0.83 | P2RX7 (0.41) | HDAC1HDAC2 | |
| SCHEMBL1952393 | 0.83 | ADORA2A (0.49) | HDAC1HDAC2ADORA2AADORA1ROCK2 | |
| SCHEMBL12756737 | 0.77 | NPY5R (0.48) | HDAC1HDAC2ROCK1TP53 | |
| SCHEMBL12830908 | 0.77 | HDAC1 (0.46) | HDAC1HDAC2 | |
| SCHEMBL12562026 | 0.77 | MAOB (0.68) | HDAC1HDAC2ADORA2AADORA1ROCK2 | |
| SCHEMBL24309127 | 0.74 | MAOB (0.56) | HDAC1HDAC2ADORA2AADORA1ROCK2 | |
| SCHEMBL29458816 | 0.74 | MAOB (0.56) | HDAC1HDAC2ADORA2AADORA1ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140051711-A1 | COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM | CALCIMEDICA INC. (US) | 2014-02-20 | — | — | US | disclosed |
| US-20140051711-A1 | COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM | CALCIMEDICA INC. (US) | 2014-02-20 | — | — | US | disclosed |
| WO-2011034962-A2 | COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM | CALCIMEDICA INC. (US) | 2011-03-24 | — | — | WO | disclosed |
| US-20110065724-A1 | COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM | CALCIMEDICA, INC. (US) | 2011-03-17 | — | — | US | disclosed |
| US-20110065724-A1 | COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM | CALCIMEDICA, INC. (US) | 2011-03-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140051711-A1 | COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM | ORAI1, SARAF, RYR2 | HDAC1 2696/4885HDAC2 2333/4885ADORA2A 1775/4885 |
| US-20110065724-A1 | COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM | ORAI1, SARAF, RYR2 | HDAC1 2696/4885HDAC2 2333/4885ADORA2A 1775/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.