Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | XIAP | P98170 | 8/20 | 0.73 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.57 |
| ▸ | ALOX5 | P09917 | 9/20 | 0.46 |
| ▸ | MPEG1 | Q2M385 | 7/20 | 0.46 |
| ▸ | GPR84 | Q9NQS5 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | PTGES | O14684 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12757274 | 0.84 | XIAP (1.00) | XIAPCYP2C9MAPK1CYP1A2HIF1A | |
| SCHEMBL12757282 | 0.79 | XIAP (1.00) | XIAPCYP2C9MAPK1ALOX5MPEG1 | |
| SCHEMBL29506228 | 0.74 | CYP1A2 (0.77) | CYP2C9MAPK1CYP1A2HIF1AMEN1 | |
| SCHEMBL14765070 | 0.74 | CYP1A2 (0.77) | CYP2C9MAPK1CYP1A2HIF1AMEN1 | |
| SCHEMBL9175113 | 0.71 | XIAP (1.00) | XIAPCYP2C9MAPK1ALOX5MPEG1 | |
| SCHEMBL9580649 | 0.69 | ALOX5 (0.83) | XIAPCYP2C9MAPK1ALOX5MPEG1 | |
| SCHEMBL22139397 | 0.69 | XIAP (0.41) | XIAPCYP2C9MAPK1CYP1A2HIF1A | |
| SCHEMBL27623517 | 0.68 | MAOA (0.57) | CYP2C9MAPK1CYP1A2HIF1APTPN1 | |
| SCHEMBL10934636 | 0.67 | CYP1A2 (0.51) | XIAPCYP2C9MAPK1CYP1A2HIF1A | |
| SCHEMBL3044017 | 0.65 | HIF1A (0.48) | CYP2C9MAPK1CYP1A2HIF1AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7910621-B2 | Small molecule antagonists of XIAP family proteins | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2011-03-22 | — | — | US | disclosed |
| US-20080021095-A1 | Small Molecule Antagonists of Xiap Family Proteins | THE REGENTS OF THE UNIVERSITY OF MICHIGAN | 2008-01-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080021095-A1 | Small Molecule Antagonists of Xiap Family Proteins | XIAP, BIRC5, BIRC3 | XIAP 1/4885CYP2C9 4873/4885MAPK1 3102/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.