SCHEMBL12759665

SCHEMBL12759665

OC(c1ccsc1)(C(F)(F)F)C(F)(F)F

nearest known ligand 0.46

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
NR1H2 P55055 13/20 0.43
NR1H3 Q13133 13/20 0.43
MLYCD O95822 1/20 0.42
SMN1; SMN2 Q16637 2/20 0.37
AR P10275 1/20 0.36
MEN1 O00255 1/20 0.36
ALOX15 P16050 1/20 0.36
TSHR P16473 1/20 0.36
MAPK1 P28482 1/20 0.36
KMT2A Q03164 1/20 0.36
HSD17B10 Q99714 1/20 0.36
RORA P35398 1/20 0.36
RORC P51449 1/20 0.36
RORB Q92753 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL827480 0.77
SCHEMBL6315499 0.76
SCHEMBL30295392 0.75 ESR1 (0.42)
SCHEMBL18407899 0.75
SCHEMBL3385140 0.73 PDK2 (0.48) NR1H2NR1H3MLYCDRORARORC
SCHEMBL131990 0.73 NR1H2 (0.68) NR1H2NR1H3MLYCDSMN1; SMN2
SCHEMBL18885491 0.73
SCHEMBL2975836 0.73
SCHEMBL25710862 0.73 CHRM3 (0.33)
Formic Acid SCHEMBL27883763 0.71 CES2 (0.35) MEN1TSHRKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9267908-B2 Devices and methods for determination of species including chemical warfare agents MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) 2016-02-23 US disclosed
US-20160011135-A1 DEVICES AND METHODS FOR DETERMINATION OF SPECIES INCLUDING CHEMICAL WARFARE AGENTS MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) 2016-01-14 US disclosed
US-8951473-B2 Devices and methods for determination of species including chemical warfare agents MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) 2015-02-10 US disclosed
US-20110089051-A1 DEVICES AND METHODS FOR DETERMINATION OF SPECIES INCLUDING CHEMICAL WARFARE AGENTS MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) 2011-04-21 US disclosed