SCHEMBL1276012

SCHEMBL1276012

Cc1cc(-n2nc3ccc(Cl)cc3n2)cc(C(C)(C)C)c1O

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 6/20 0.42
MEN1 O00255 4/20 0.42
KMT2A Q03164 4/20 0.42
ATM Q13315 3/20 0.42
CYP1A2 P05177 1/20 0.41
CYP2C9 P11712 1/20 0.41
CYP2C19 P33261 1/20 0.41
RAB9A P51151 5/20 0.40
MAPT P10636 5/20 0.40
KDM4E B2RXH2 2/20 0.40
PPARG P37231 1/20 0.39
PPARA Q07869 1/20 0.39
TP53 P04637 2/20 0.36
THRB P10828 1/20 0.35
SMN1; SMN2 Q16637 3/20 0.35
ALDH1A1 P00352 2/20 0.35
GAA P10253 1/20 0.35
HPGD P15428 1/20 0.35
CASP1 P29466 1/20 0.35
CASP7 P55210 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29481344 1.00 NPC1 (0.42) NPC1MEN1KMT2AATMCYP1A2
SCHEMBL3900613 0.92 NPC1 (0.44) NPC1MEN1KMT2AATMRAB9A
SCHEMBL11459762 0.87 NPC1 (0.49) NPC1MEN1KMT2AATMRAB9A
SCHEMBL2549815 0.85 PPARG (0.52) NPC1MEN1KMT2ACYP1A2CYP2C9
SCHEMBL9777445 0.81 NPC1 (0.39) NPC1MEN1KMT2AATMRAB9A
SCHEMBL9261254 0.81 NPC1 (0.38) NPC1MEN1KMT2AATMCYP1A2
SCHEMBL31385446 0.81 NPC1 (0.35) NPC1MEN1KMT2AATMCYP1A2
Bumetrizole SCHEMBL8603228 0.79 NPC1 (0.53) NPC1MEN1KMT2AATMCYP1A2
Bumetrizole SCHEMBL8054070 0.79 NPC1 (0.53) NPC1MEN1KMT2AATMCYP1A2
Bumetrizole SCHEMBL2398487 0.79 NPC1 (0.53) NPC1MEN1KMT2AATMCYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-107924120-B Method for producing mixed printing dots in flexographic printing plates 麦德美图形解决方案有限责任公司 2021-04-13 CN claimed
CN-116948234-A High-hardness anti-UV anti-dazzle film and preparation method thereof 江苏斯迪克新材料科技股份有限公司 2023-10-27 CN disclosed
CN-116917377-A Optically transparent polyamideimide 齐默尔根公司 2023-10-20 CN disclosed
US-20230167336-A1 ADHESIVE SHEET NITTO DENKO CORPORATION (JP) 2023-06-01 US disclosed
CN-110389475-B Optical plate with protruding part, optical structure, backlight module and display device 奇美实业股份有限公司 2022-04-05 CN disclosed
CN-107924120-B Method for producing mixed printing dots in flexographic printing plates 麦德美图形解决方案有限责任公司 2021-04-13 CN disclosed
CN-107533242-B Plastic lens 东海光学株式会社 2020-06-26 CN disclosed
CN-106842392-B Building material plate, manufacturing method and application thereof 奇美实业股份有限公司 2019-12-17 CN disclosed
EP-2589632-A1 WHEEL-PROTECTING FILM Nitto Denko Corporation (JP) 2013-05-08 EP disclosed
US-20110028603-A1 HYPERBRANCHED POLYMERS AND OLIGOMERS COMPRISING TERMINAL AMINO GROUPS AS CURING AGENTS FOR EPOXY RESINS BASF SE (DE) 2011-02-03 US disclosed
US-5583088-A ELECTRON DONOR, ELECTRON ACCEPTOR, DECOLORIZATION PROMOTER AGENT, BINDER RESIN RICOH COMPANY, LTD. (JP) 1996-12-10 US disclosed