Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.75 |
| ▸ | GAA | P10253 | 2/20 | 0.65 |
| ▸ | ATM | Q13315 | 1/20 | 0.65 |
| ▸ | LMNA | P02545 | 1/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.62 |
| ▸ | PKM | P14618 | 3/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.60 |
| ▸ | MEN1 | O00255 | 1/20 | 0.60 |
| ▸ | POLB | P06746 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.60 |
| ▸ | CA12 | O43570 | 1/20 | 0.59 |
| ▸ | CA1 | P00915 | 1/20 | 0.59 |
| ▸ | CA2 | P00918 | 1/20 | 0.59 |
| ▸ | CA7 | P43166 | 1/20 | 0.59 |
| ▸ | CA9 | Q16790 | 1/20 | 0.59 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1945511 | 0.86 | L3MBTL1 (0.81) | L3MBTL1ATMLMNAKMT2AMEN1 | |
| SCHEMBL12761130 | 0.86 | ATM (0.65) | L3MBTL1ATMLMNACA12CA1 | |
| SCHEMBL1946614 | 0.86 | L3MBTL1 (0.75) | L3MBTL1ATMLMNAKMT2AMEN1 | |
| SCHEMBL10717731 | 0.85 | CA12 (0.66) | L3MBTL1GAALMNAPKMKMT2A | |
| SCHEMBL10674722 | 0.85 | CA12 (0.66) | L3MBTL1GAALMNAPKMKMT2A | |
| SCHEMBL3714000 | 0.85 | GPR183 (0.65) | L3MBTL1LMNAPKMKMT2AMEN1 | |
| Hydrochloric Acid SCHEMBL10719352 | 0.84 | CA12 (0.64) | L3MBTL1GAALMNAPKMKMT2A | |
| SCHEMBL752734 | 0.83 | L3MBTL1 (0.65) | L3MBTL1GAAATMLMNASMN1; SMN2 | |
| SCHEMBL1947493 | 0.82 | L3MBTL1 (0.64) | L3MBTL1ATMLMNASMN1; SMN2KMT2A | |
| SCHEMBL10670607 | 0.82 | ALDH1A1 (0.67) | L3MBTL1PKMKMT2AMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2346828-B1 | PIPERAZINE DERIVATIVES USED AS CAV2.2 CALCIUM CHANNEL MODULATORS | CONVERGENCE PHARMACEUTICALS (GB) | 2012-10-03 | — | — | EP | claimed |
| EP-2346828-B1 | PIPERAZINE DERIVATIVES USED AS CAV2.2 CALCIUM CHANNEL MODULATORS | CONVERGENCE PHARMACEUTICALS (GB) | 2012-10-03 | — | — | EP | disclosed |