Dymanthine

Dymanthine

SCHEMBL1276492

CCCCCCCCCCCCCCCCCC[NH+](C)C.Oc1ccccc1[B-](c1c(F)c(F)c(F)c(F)c1F)(c1c(F)c(F)c(F)c(F)c1F)c1c(F)c(F)c(F)c(F)c1F

nearest known ligand 0.40

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Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
DNM1 Q05193 1/20 0.40
MEN1 O00255 2/20 0.33
MAPT P10636 2/20 0.33
HTT P42858 2/20 0.33
KMT2A Q03164 2/20 0.33
TP53 P04637 1/20 0.33
CYP3A4 P08684 1/20 0.33
ALOX5 P09917 1/20 0.33
TYR P14679 1/20 0.33
ALOX15 P16050 1/20 0.33
TSHR P16473 1/20 0.33
TDP1 Q9NUW8 1/20 0.33
BID P55957 3/20 0.33
MCL1 Q07820 3/20 0.33
BCL2L1 Q07817 2/20 0.33
BAK1 Q16611 2/20 0.33
KAT8 Q9H7Z6 2/20 0.33
NAAA Q02083 1/20 0.33
PPARG P37231 1/20 0.33
PPARA Q07869 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5656345 0.92 MEN1 (0.33) MEN1MAPTHTTKMT2ATP53
SCHEMBL5872296 0.92 MEN1 (0.33) MEN1MAPTHTTKMT2ATP53
SCHEMBL5653811 0.92 MEN1 (0.33) MEN1MAPTHTTKMT2ATP53
SCHEMBL1276666 0.90 MEN1 (0.35) MEN1MAPTHTTKMT2ATP53
SCHEMBL6462737 0.87 NAAA (0.32) MEN1MAPTHTTKMT2ANAAA
SCHEMBL5655348 0.86 BID (0.31) MEN1MAPTHTTKMT2ABID
SCHEMBL30240774 0.86 BID (0.31) MEN1MAPTHTTKMT2ABID
SCHEMBL29661112 0.83 MEN1 (0.33) MEN1MAPTHTTKMT2ATP53
SCHEMBL5655310 0.82 MGLL (0.30)
SCHEMBL5656636 0.81 PTGS1 (0.30)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2459603-B1 POLYMERIZATION PROCESS USING A SUPPORTED CONSTRAINED GEOMETRY CATALYST UNIVATION TECH LLC (US) 2014-07-02 EP disclosed
EP-2459603-A1 POLYMERIZATION PROCESS USING A SUPPORTED CONSTRAINED GEOMETRY CATALYST Univation Technologies, LLC (US) 2012-06-06 EP disclosed
WO-2011017092-A1 POLYMERIZATION PROCESS USING A SUPPORTED CONSTRAINED GEOMETRY CATALYST UNIVATION TECHNOLOGIES, LLC (US) 2011-02-10 WO disclosed
EP-0971962-B1 CATALYST SYSTEM FOR HIGH YIELD SYNTHESIS OF POLYOLEFINS BP CHEM INT LTD (GB) 2004-02-11 EP disclosed
US-6479599-B1 Catalyst system for high yield synthesis of polyolefins BP CHEMICALS LIMITED (GB) 2002-11-12 US disclosed
EP-0971962-A1 CATALYST SYSTEM FOR HIGH YIELD SYNTHESIS OF POLYOLEFINS THE DOW CHEMICAL COMPANY (US) 2000-01-19 EP disclosed
WO-1998045337-A1 CATALYST SYSTEM FOR HIGH YIELD SYNTHESIS OF POLYOLEFINS THE DOW CHEMICAL COMPANY (US) 1998-10-15 WO disclosed