Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GBA1 | P04062 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.38 |
| ▸ | EP300 | Q09472 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.35 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1641579 | 1.00 | GBA1 (0.42) | GBA1SLC6A4ALDH1A1SLC6A2PRKCZ | |
| SCHEMBL8247174 | 0.83 | GBA1 (0.44) | GBA1SLC6A4PRKCZEP300HRH3 | |
| SCHEMBL21788553 | 0.81 | SLC6A4 (0.58) | GBA1SLC6A4SLC6A2KCNH2 | |
| SCHEMBL31203132 | 0.79 | HTR1D (0.43) | ALDH1A1HRH3HRH4 | |
| SCHEMBL1641578 | 0.79 | GBA1 (0.41) | GBA1SLC6A4SLC6A2KCNH2HRH3 | |
| SCHEMBL3966077 | 0.76 | GBA1 (0.56) | GBA1SLC6A4SLC6A2KCNH2HTR2C | |
| SCHEMBL31203053 | 0.75 | ALDH1A1 (0.46) | GBA1SLC6A4ALDH1A1 | |
| SCHEMBL20135654 | 0.74 | SLC6A2 (0.47) | SLC6A4SLC6A2KCNH2HRH3HRH4 | |
| SCHEMBL31406342 | 0.74 | ALDH1A1 (0.45) | ALDH1A1PDE10A | |
| SCHEMBL28838405 | 0.73 | F2 (0.41) | GBA1SLC6A4HRH3HRH4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110098296-A1 | Thiazole And Oxazole Kinase Inhibitors | GLAXOSMITHKLINE LLC | 2011-04-28 | — | — | US | disclosed |
| WO-2009076140-A1 | THIAZOLE AND OXAZOLE KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110098296-A1 | Thiazole And Oxazole Kinase Inhibitors | PDXK, MAP3K1, MAP4K2 | GBA1 4328/4885SLC6A4 3995/4885ALDH1A1 3014/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.