Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B3 | P37058 | 3/20 | 0.37 |
| ▸ | SRD5A1 | P18405 | 3/20 | 0.36 |
| ▸ | PNMT | P11086 | 3/20 | 0.36 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.36 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.33 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.33 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.33 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.33 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.33 |
| ▸ | TYMS | P04818 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
| ▸ | HTR2C | P28335 | 1/20 | 0.32 |
| ▸ | HTR2B | P41595 | 1/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2973732 | 0.82 | ALDH1A1 (0.37) | HSD17B3PNMTASIC3ADRA2AADRA2B | |
| SCHEMBL13239080 | 0.79 | SRD5A1 (0.37) | SRD5A1PARP10PARP11CYP11B1CYP11B2 | |
| SCHEMBL14613178 | 0.76 | CASP1 (0.41) | HSD17B3CYP11B1CYP11B2 | |
| SCHEMBL16532176 | 0.76 | SRD5A1 (0.40) | HSD17B3SRD5A1PNMTASIC3SRD5A2 | |
| SCHEMBL26233911 | 0.76 | ADRA2A (0.36) | PNMTADRA2AADRA2BADRA2CCYP11B1 | |
| SCHEMBL24022797 | 0.76 | CYP11B1 (0.32) | CYP11B1CYP11B2 | |
| SCHEMBL806484 | 0.72 | CYP11B1 (0.50) | PNMTCYP11B1CYP11B2CYP19A1 | |
| SCHEMBL18144799 | 0.72 | CYP11B1 (0.51) | SRD5A1PNMTASIC3SRD5A2TDP1 | |
| SCHEMBL12812833 | 0.71 | NPC1 (0.49) | — | |
| SCHEMBL5029738 | 0.70 | KDM1A (0.46) | ADRA2ACYP11B1CYP11B2CYP19A1HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7902191-B2 | Histamine H3 receptor antagonists, preparation and therapeutic uses | ELI LILLY AND COMPANY (US) | 2011-03-08 | — | — | US | disclosed |
| US-20070155754-A1 | Histamine h3 receptor antagonists, preparation and therapeutic uses | ELI LILLY AND COMPANY | 2007-07-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070155754-A1 | Histamine h3 receptor antagonists, preparation and therapeutic uses | HRH3, HRH4, HRH2 | HSD17B3 1495/4885SRD5A1 2867/4885PNMT 264/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.