Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAC1 | P63000 | 4/20 | 0.52 |
| ▸ | PDE4A | P27815 | 10/20 | 0.45 |
| ▸ | PDE4B | Q07343 | 10/20 | 0.45 |
| ▸ | PDE4C | Q08493 | 10/20 | 0.45 |
| ▸ | PDE4D | Q08499 | 10/20 | 0.45 |
| ▸ | PDE3B | Q13370 | 10/20 | 0.45 |
| ▸ | PDE3A | Q14432 | 10/20 | 0.45 |
| ▸ | PDE5A | O76074 | 9/20 | 0.45 |
| ▸ | PDE1A | P54750 | 8/20 | 0.45 |
| ▸ | PDE1B | Q01064 | 8/20 | 0.45 |
| ▸ | PDE1C | Q14123 | 8/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL195376 | 0.86 | RAC1 (0.69) | RAC1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL128807 | 0.84 | RAC1 (0.46) | RAC1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL129941 | 0.81 | RAC1 (0.43) | RAC1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL129769 | 0.80 | PDE5A (0.41) | RAC1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL9985556 | 0.76 | RAC1 (0.48) | RAC1MEN1KMT2AGAAPOLB | |
| SCHEMBL14927116 | 0.72 | RAC1 (0.42) | RAC1GAAKDM4EMAPTALDH1A1 | |
| SCHEMBL14904055 | 0.72 | PDGFRB (0.49) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL127673 | 0.71 | RAC1 (0.40) | RAC1MEN1KMT2AGAAPOLB | |
| SCHEMBL9985559 | 0.70 | TDO2 (0.39) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL14930629 | 0.69 | RAC1 (0.60) | RAC1MEN1KMT2AGAAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9227966-B2 | Antimicrobial agents | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) | 2016-01-05 | — | — | US | disclosed |
| US-8933096-B2 | Antimicrobial agents | Rugers, The State University of New Jersey (US) | 2015-01-13 | — | — | US | disclosed |
| US-20140315939-A1 | ANTIMICROBIAL AGENTS | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) | 2014-10-23 | — | — | US | disclosed |
| US-20130116278-A1 | ANTIMICROBIAL AGENTS | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY | 2013-05-09 | — | — | US | disclosed |
| US-20120059026-A1 | ANTIMICROBIAL AGENTS | UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY (US) | 2012-03-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130116278-A1 | ANTIMICROBIAL AGENTS | MRPL21, ARG1, RPP30 | RAC1 356/4885PDE4A 2153/4885PDE4B 2021/4885 |
| US-20120059026-A1 | ANTIMICROBIAL AGENTS | ZYX, Q6ZSR9, ZC3HAV1L | RAC1 331/4885PDE4A 1469/4885PDE4B 1251/4885 |
| US-20140315939-A1 | ANTIMICROBIAL AGENTS | ZYX, Q6ZSR9, ZC3HAV1L | RAC1 254/4885PDE4A 1919/4885PDE4B 1783/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.