Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKACA | P17612 | 4/20 | 0.72 |
| ▸ | PRKACG | P22612 | 4/20 | 0.72 |
| ▸ | PRKACB | P22694 | 4/20 | 0.72 |
| ▸ | ROCK2 | O75116 | 6/20 | 0.62 |
| ▸ | DYRK1A | Q13627 | 6/20 | 0.55 |
| ▸ | GSK3B | P49841 | 1/20 | 0.55 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.53 |
| ▸ | ITK | Q08881 | 4/20 | 0.51 |
| ▸ | AURKA | O14965 | 1/20 | 0.51 |
| ▸ | WNT1 | P04628 | 3/20 | 0.49 |
| ▸ | CLK2 | P49760 | 1/20 | 0.49 |
| ▸ | CLK3 | P49761 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1647780 | 0.84 | PRKACA (1.00) | PRKACAPRKACGPRKACBROCK2ROCK1 | |
| SCHEMBL12779328 | 0.83 | PRKACA (0.72) | PRKACAPRKACGPRKACBROCK2ROCK1 | |
| SCHEMBL6219544 | 0.83 | DYRK1A (0.72) | DYRK1AGSK3BWNT1CLK2CLK3 | |
| SCHEMBL12779512 | 0.82 | KDM4E (0.65) | PRKACAPRKACGPRKACBROCK2DYRK1A | |
| SCHEMBL14712592 | 0.81 | ITK (0.75) | PRKACAPRKACGPRKACBDYRK1AITK | |
| SCHEMBL954666 | 0.81 | KDM4E (0.64) | — | |
| SCHEMBL1647259 | 0.80 | PRKACA (0.67) | PRKACAPRKACGPRKACBROCK2DYRK1A | |
| SCHEMBL12779509 | 0.79 | NUDT1 (0.49) | PRKACAPRKACGPRKACBDYRK1AWNT1 | |
| SCHEMBL1647894 | 0.79 | ROCK2 (0.72) | PRKACAPRKACGPRKACBROCK2DYRK1A | |
| SCHEMBL12779518 | 0.79 | PRKACA (0.63) | PRKACAPRKACGPRKACBROCK2DYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011050245-A1 | BICYCLIC HETEROARYLS AS KINASE INHIBITORS | FENG YANGBO (US) | 2011-04-28 | — | — | WO | disclosed |