Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKACA | P17612 | 7/20 | 1.00 |
| ▸ | PRKACG | P22612 | 7/20 | 1.00 |
| ▸ | PRKACB | P22694 | 7/20 | 1.00 |
| ▸ | ROCK2 | O75116 | 14/20 | 0.88 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.70 |
| ▸ | ROCK1 | Q13464 | 9/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12779305 | 0.94 | ROCK2 (1.00) | PRKACAPRKACGPRKACBROCK2SMN1; SMN2 | |
| SCHEMBL1647886 | 0.91 | PRKACA (0.83) | PRKACAPRKACGPRKACBROCK2SMN1; SMN2 | |
| SCHEMBL12779421 | 0.87 | PRKACA (0.77) | PRKACAPRKACGPRKACBROCK2SMN1; SMN2 | |
| SCHEMBL1649565 | 0.84 | PRKACA (1.00) | PRKACAPRKACGPRKACBROCK2ROCK1 | |
| SCHEMBL12779513 | 0.84 | PRKACA (0.72) | PRKACAPRKACGPRKACBROCK2ROCK1 | |
| SCHEMBL1647566 | 0.83 | PRKACA (0.80) | PRKACAPRKACGPRKACBROCK2ROCK1 | |
| SCHEMBL1647278 | 0.83 | PRKACA (1.00) | PRKACAPRKACGPRKACBROCK2ROCK1 | |
| SCHEMBL1647894 | 0.82 | ROCK2 (0.72) | PRKACAPRKACGPRKACBROCK2ROCK1 | |
| SCHEMBL12779302 | 0.81 | ROCK2 (0.78) | PRKACAPRKACGPRKACBROCK2SMN1; SMN2 | |
| SCHEMBL3812995 | 0.81 | ROCK2 (0.76) | PRKACAPRKACGPRKACBROCK2ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011050245-A1 | BICYCLIC HETEROARYLS AS KINASE INHIBITORS | FENG YANGBO (US) | 2011-04-28 | — | — | WO | disclosed |
| WO-2011050245-A1 | BICYCLIC HETEROARYLS AS KINASE INHIBITORS | FENG YANGBO (US) | 2011-04-28 | — | — | WO | disclosed |