Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.52 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | FAAH | O00519 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.44 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.44 |
| ▸ | HTR2C | P28335 | 1/20 | 0.44 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.44 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.44 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.44 |
| ▸ | HTR2B | P41595 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19768977 | 0.87 | HTT (0.51) | HPGDFAAHCA1CA2LMNA | |
| SCHEMBL12779603 | 0.87 | HPGD (0.50) | HPGDFAAHCA1CA2LMNA | |
| SCHEMBL12569566 | 0.84 | L3MBTL1 (0.52) | HPGDFAAHCA1CA2LMNA | |
| SCHEMBL11139094 | 0.81 | RXFP1 (0.56) | RXFP1SIGMAR1HPGDCHEK1AURKA | |
| SCHEMBL12845076 | 0.81 | RXFP1 (0.56) | RXFP1SIGMAR1HPGDCYP3A4CHEK1 | |
| SCHEMBL7863594 | 0.80 | RXFP1 (0.59) | RXFP1SIGMAR1HPGDCHEK1AURKA | |
| SCHEMBL14639811 | 0.78 | RXFP1 (0.54) | RXFP1SIGMAR1HPGDGABRA1TSHR | |
| SCHEMBL13947807 | 0.78 | RXFP1 (0.56) | RXFP1SIGMAR1CA1CA2CHEK1 | |
| SCHEMBL8607311 | 0.77 | RXFP1 (0.52) | RXFP1SIGMAR1HPGDCA2CHEK1 | |
| SCHEMBL13031082 | 0.77 | RXFP1 (0.52) | RXFP1SIGMAR1HPGDHSP90AA1HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7897606-B2 | 5,6-di-substituted oxadiazolopyrazines and thiadiazolopyrazines as CXC-chemokine receptor ligands | SCHERING CORPORATION (US) | 2011-03-01 | — | — | US | disclosed |
| US-7718678-B2 | Di-substituted oxadiazoles as CXC-chemokine receptor ligands | SCHERING CORPORATION (US) | 2010-05-18 | — | — | US | disclosed |
| US-20070015731-A1 | 5,6-Di-substituted oxadiazolopyrazines and thiadiazolopyrazines as CXC-chemokine receptor ligands | MERCK SHARP & DOHME CORP. | 2007-01-18 | — | — | US | disclosed |
| US-20070015731-A1 | 5,6-Di-substituted oxadiazolopyrazines and thiadiazolopyrazines as CXC-chemokine receptor ligands | MERCK SHARP & DOHME CORP. | 2007-01-18 | — | — | US | disclosed |
| US-20070004682-A1 | Di-substituted oxadiazoles as CXC-chemokine receptor ligands | SCHERING CORPORATION | 2007-01-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070015731-A1 | 5,6-Di-substituted oxadiazolopyrazines and thiadiazolopyrazines as CXC-chemokine receptor ligands | CXCR5, CCR5, CXCR1 | RXFP1 625/4885SIGMAR1 1130/4885HPGD 69/4885 |
| US-20070004682-A1 | Di-substituted oxadiazoles as CXC-chemokine receptor ligands | CXCR3, CXCR1, CXCR2 | RXFP1 174/4885SIGMAR1 329/4885HPGD 81/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.