Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Arginine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 2/20 | 0.41 |
| ▸ | SLC7A11 | Q9UPY5 | 1/20 | 0.41 |
| ▸ | OTC | P00480 | 1/20 | 0.41 |
| ▸ | DDAH1 | O94760 | 3/20 | 0.39 |
| ▸ | GSR | P00390 | 2/20 | 0.37 |
| ▸ | NOS2 | P35228 | 6/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | APEX1 | P27695 | 1/20 | 0.37 |
| ▸ | NOS3 | P29474 | 5/20 | 0.37 |
| ▸ | NOS1 | P29475 | 5/20 | 0.37 |
| ▸ | GSTK1 | Q9Y2Q3 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | GRM8 | O00222 | 1/20 | 0.33 |
| ▸ | GRM6 | O15303 | 1/20 | 0.33 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Arginine SCHEMBL909965 | 1.00 | PTGS1 (0.41) | PTGS1SLC7A11OTCDDAH1GSR | |
| Arginine SCHEMBL22360939 | 1.00 | PTGS1 (0.41) | PTGS1SLC7A11OTCDDAH1GSR | |
| Arginine SCHEMBL5078038 | 0.96 | PTGS1 (0.44) | PTGS1SLC7A11OTCDDAH1GSR | |
| Arginine SCHEMBL9188925 | 0.96 | PTGS1 (0.44) | PTGS1SLC7A11OTCDDAH1GSR | |
| Arginine SCHEMBL9188915 | 0.96 | PTGS1 (0.44) | PTGS1SLC7A11OTCDDAH1GSR | |
| Arginine SCHEMBL27757865 | 0.95 | GSR (0.47) | PTGS1SLC7A11OTCDDAH1GSR | |
| Arginine SCHEMBL28213702 | 0.95 | OTC (0.38) | PTGS1SLC7A11OTCDDAH1GSR | |
| Arginine SCHEMBL28213703 | 0.95 | PTGS1 (0.46) | PTGS1SLC7A11OTCDDAH1GSR | |
| Arginine SCHEMBL20678167 | 0.95 | PTGS1 (0.46) | PTGS1SLC7A11OTCDDAH1GSR | |
| Arginine SCHEMBL16637167 | 0.95 | PTGS1 (0.46) | PTGS1SLC7A11OTCDDAH1GSR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10300167-B2 | Functionalized calcium phosphate artificial bone and joint compositions and methods of use and manufacture | Cabertech, Inc. (US) | 2019-05-28 | — | — | US | claimed |
| EP-2739265-A1 | FUNCTIONALIZED CALCIUM PHOSPHATE ARTIFICIAL BONE AND JOINT COMPOSITIONS AND METHODS OF USE AND MANUFACTURE | Cabertech, Inc. (US) | 2014-06-11 | — | — | EP | claimed |
| WO-2013016006-A1 | FUNCTIONALIZED CALCIUM PHOSPHATE ARTIFICIAL BONE AND JOINT COMPOSITIONS AND METHODS OF USE AND MANUFACTURE | Cabertech, Inc. (US) | 2013-01-31 | — | — | WO | claimed |
| US-20120087950-A1 | FUNCTIONALIZED CALCIUM PHOSPHATE ARTIFICIAL BONE AND JOINT COMPOSITIONS AND METHODS OF USE AND MANUFACTURE | DUQUESNE UNIVERSITY OF THE HOLY SPIRIT | 2012-04-12 | — | — | US | claimed |
| US-11771767-B2 | Reduced and oxidized polysaccharides and methods of use thereof | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2023-10-03 | — | — | US | disclosed |
| EP-3730160-B1 | CLICK-CROSSLINKED HYDROGELS AND METHODS OF USE | HARVARD COLLEGE (US) | 2023-06-07 | — | — | EP | disclosed |
| EP-3821880-A1 | OXIDIZED POLYSACCHARIDES AND METHODS OF USE THEREOF | President and Fellows of Harvard College (US) | 2021-05-19 | — | — | EP | disclosed |
| US-20210128790-A1 | CLICK-CROSSLINKED HYDROGELS AND METHODS OF USE | NATIONAL INSTITUTE OF HEALTH (NIH), U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2021-05-06 | — | — | US | disclosed |
| US-20200368359-A1 | REDUCED AND OXIDIZED POLYSACCHARIDES AND METHODS OF USE THEREOF | PRESIDENT AND FELLOWS OF HARVARD COLLEGE | 2020-11-26 | — | — | US | disclosed |
| US-10821208-B2 | Click-crosslinked hydrogels and methods of use | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2020-11-03 | — | — | US | disclosed |
| EP-3730160-A1 | CLICK-CROSSLINKED HYDROGELS AND METHODS OF USE | President and Fellows of Harvard College (US) | 2020-10-28 | — | — | EP | disclosed |
| EP-3368016-B1 | REDUCED AND OXIDIZED POLYSACCHARIDES AND METHODS OF USE THEREOF | HARVARD COLLEGE (US) | 2020-10-21 | — | — | EP | disclosed |
| US-20170189581-A1 | CLICK-CROSSLINKED HYDROGELS AND METHODS OF USE | PRESIDENT AND FELLOWS OF HARVARD COLLEGE | 2017-07-06 | — | — | US | disclosed |
| WO-2017075055-A1 | REDUCED AND OXIDIZED POLYSACCHARIDES AND METHODS OF USE THEREOF | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2017-05-04 | — | — | WO | disclosed |
| EP-3125960-A1 | CLICK-CROSSLINKED HYDROGELS AND METHODS OF USE | President and Fellows of Harvard College (US) | 2017-02-08 | — | — | EP | disclosed |
| WO-2015154078-A1 | CLICK-CROSSLINKED HYDROGELS AND METHODS OF USE | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2015-10-08 | — | — | WO | disclosed |
| EP-2739265-A1 | FUNCTIONALIZED CALCIUM PHOSPHATE ARTIFICIAL BONE AND JOINT COMPOSITIONS AND METHODS OF USE AND MANUFACTURE | Cabertech, Inc. (US) | 2014-06-11 | — | — | EP | disclosed |
| WO-2013016006-A1 | FUNCTIONALIZED CALCIUM PHOSPHATE ARTIFICIAL BONE AND JOINT COMPOSITIONS AND METHODS OF USE AND MANUFACTURE | Cabertech, Inc. (US) | 2013-01-31 | — | — | WO | disclosed |
| US-20120087950-A1 | FUNCTIONALIZED CALCIUM PHOSPHATE ARTIFICIAL BONE AND JOINT COMPOSITIONS AND METHODS OF USE AND MANUFACTURE | DUQUESNE UNIVERSITY OF THE HOLY SPIRIT | 2012-04-12 | — | — | US | disclosed |
| US-20070224678-A1 | Functionalized artificial bone and joint compositions and methods of use and manufacture | DUQUESNE UNIVERSITY OF THE HOLY SPIRIT | 2007-09-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210128790-A1 | CLICK-CROSSLINKED HYDROGELS AND METHODS OF USE | VCL, CD44, LOX | PTGS1 574/4885SLC7A11 1333/4885OTC 2785/4885 |
| US-11771767-B2 | Reduced and oxidized polysaccharides and methods of use thereof | ALG1, LPO, FUT5 | PTGS1 1617/4885SLC7A11 2338/4885OTC 188/4885 |
| US-20170189581-A1 | CLICK-CROSSLINKED HYDROGELS AND METHODS OF USE | VCL, CD44, LOX | PTGS1 574/4885SLC7A11 1333/4885OTC 2785/4885 |
| US-20200368359-A1 | REDUCED AND OXIDIZED POLYSACCHARIDES AND METHODS OF USE THEREOF | ALG1, LPO, FUT5 | PTGS1 1617/4885SLC7A11 2338/4885OTC 188/4885 |
| US-10821208-B2 | Click-crosslinked hydrogels and methods of use | VCL, CD44, LOX | PTGS1 574/4885SLC7A11 1333/4885OTC 2785/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.