Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2B | P29275 | 20/20 | 0.43 |
| ▸ | ADORA1 | P30542 | 8/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 5/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1712944 | 0.87 | ADORA2B (0.44) | ADORA2BADORA1ADORA2AADORA3 | |
| SCHEMBL2077334 | 0.84 | ADORA2B (0.44) | ADORA2BADORA1ADORA2AADORA3 | |
| SCHEMBL1713579 | 0.84 | CYP3A4 (0.44) | ADORA2BADORA1ADORA2AADORA3 | |
| Trifluoroacetic Acid SCHEMBL1713254 | 0.79 | ADORA2B (0.42) | ADORA2BADORA1ADORA2AADORA3 | |
| Trifluoroacetic Acid SCHEMBL1713093 | 0.79 | ADORA2B (0.44) | ADORA2BADORA1ADORA2AADORA3 | |
| SCHEMBL1713205 | 0.75 | ADORA2A (0.36) | ADORA2BADORA1ADORA2AADORA3 | |
| SCHEMBL1713216 | 0.72 | ADORA2B (0.43) | ADORA2BADORA1ADORA2AADORA3 | |
| SCHEMBL1713067 | 0.72 | PDE4A (0.48) | ADORA2BADORA1ADORA2AADORA3 | |
| SCHEMBL1713177 | 0.72 | ADORA2B (0.49) | ADORA2BADORA1ADORA2AADORA3 | |
| SCHEMBL1713274 | 0.72 | ADORA2A (0.46) | ADORA2BADORA1ADORA2AADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7902205-B2 | Purinone derivatives as HM74A agonists | INCYTE CORPORATION (US) | 2011-03-08 | — | — | US | disclosed |
| US-7863285-B2 | Purinone derivatives as HM74A agonists | INCYTE CORPORATION (US) | 2011-01-04 | — | — | US | disclosed |
| US-20090088446-A1 | PURINONE DERIVATIVES AS HM74A AGONISTS | INCYTE CORPORATION (US) | 2009-04-02 | — | — | US | disclosed |
| US-20090076269-A1 | PURINONE DERIVATIVES AS HM74A AGONISTS | INCYTE CORPORATION (US) | 2009-03-19 | — | — | US | disclosed |
| US-7462624-B2 | Purinone derivatives as HM74a agonists | INCYTE CORPORATION (US) | 2008-12-09 | — | — | US | disclosed |
| US-20080045555-A1 | PURINONE DERIVATIVES AS HM74A AGONISTS | INCYTE CORPORATION (US) | 2008-02-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090088446-A1 | PURINONE DERIVATIVES AS HM74A AGONISTS | GPR84, P2RY1, ADRA1A | ADORA2B 68/4885ADORA1 39/4885ADORA2A 12/4885 |
| US-20090076269-A1 | PURINONE DERIVATIVES AS HM74A AGONISTS | GPR84, P2RY1, ADRA1A | ADORA2B 68/4885ADORA1 39/4885ADORA2A 12/4885 |
| US-20080045555-A1 | PURINONE DERIVATIVES AS HM74A AGONISTS | GPR84, P2RY1, ADRA1A | ADORA2B 68/4885ADORA1 39/4885ADORA2A 12/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.