Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPAR1 | Q92633 | 4/20 | 0.36 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.35 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.35 |
| ▸ | MLNR | O43193 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.34 |
| ▸ | FFAR4 | Q5NUL3 | 3/20 | 0.33 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.33 |
| ▸ | LPAR3 | Q9UBY5 | 1/20 | 0.33 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.32 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.32 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.32 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.32 |
| ▸ | PPARD | Q03181 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7121 | 0.88 | LPAR1 (0.35) | LPAR1PTGDR2SUCNR1MLNRMEN1 | |
| SCHEMBL7396 | 0.88 | CYP4F2 (0.35) | MLNRMEN1ALDH1A1KMT2A | |
| SCHEMBL6296 | 0.82 | LPAR1 (0.48) | LPAR1PTGDR2PTGS1PTGS2FFAR4 | |
| SCHEMBL7683 | 0.78 | CYP4F2 (0.33) | MLNRMEN1ALDH1A1KMT2A | |
| SCHEMBL7534 | 0.76 | L3MBTL1 (0.34) | LPAR1ALDH1A1 | |
| SCHEMBL3709527 | 0.76 | CYP2D6 (0.39) | LPAR1PTGDR2MLNRMEN1ALDH1A1 | |
| SCHEMBL7415 | 0.76 | LPAR1 (0.46) | LPAR1MEN1ALDH1A1KMT2ALPAR3 | |
| SCHEMBL14688 | 0.75 | LPAR1 (0.47) | LPAR1PTGDR2SUCNR1MEN1ALDH1A1 | |
| SCHEMBL2342592 | 0.72 | LPAR1 (0.39) | LPAR1ALDH1A1LPAR2LPAR3PPARD | |
| SCHEMBL6661 | 0.72 | FFAR1 (0.41) | LPAR1MEN1ALDH1A1KMT2AFFAR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2483252-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | Amira Pharmaceuticals, Inc. (US) | 2012-08-08 | — | — | EP | claimed |
| WO-2011041694-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | AMIRA PHARMACEUTICALS, INC. (US) | 2011-04-07 | — | — | WO | claimed |
| EP-2483252-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | Amira Pharmaceuticals, Inc. (US) | 2012-08-08 | — | — | EP | disclosed |
| WO-2011041694-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | AMIRA PHARMACEUTICALS, INC. (US) | 2011-04-07 | — | — | WO | disclosed |