Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 2/20 | 0.41 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.41 |
| ▸ | LPAR1 | Q92633 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 6/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.39 |
| ▸ | GAA | P10253 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 3/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | MPI | P34949 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6296 | 0.91 | LPAR1 (0.48) | FFAR1FFAR4LPAR1MAPTHPGD | |
| SCHEMBL7396 | 0.84 | CYP4F2 (0.35) | ALDH1A1KDM4EHPGDL3MBTL1HTT | |
| SCHEMBL7683 | 0.81 | CYP4F2 (0.33) | ALDH1A1KDM4EHPGDL3MBTL1HTT | |
| SCHEMBL6973 | 0.79 | BRD4 (0.36) | MAPTALDH1A1KDM4EGAAHPGD | |
| SCHEMBL14677 | 0.78 | LPAR1 (0.42) | FFAR1FFAR4LPAR1MAPTALDH1A1 | |
| SCHEMBL7201 | 0.78 | CHRM1 (0.42) | LPAR1MAPTALDH1A1HTTLMNA | |
| SCHEMBL7532 | 0.74 | ALOX5 (0.35) | MAPTALDH1A1KDM4EGAAHPGD | |
| SCHEMBL7666 | 0.74 | ABCC3 (0.44) | LPAR1ALDH1A1ALOX5KMT2AMEN1 | |
| SCHEMBL1800 | 0.73 | CHRM1 (0.41) | LPAR1MAPTALDH1A1ALOX5HTT | |
| SCHEMBL12783 | 0.72 | LPAR1 (0.36) | FFAR4LPAR1ALDH1A1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2483252-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | Amira Pharmaceuticals, Inc. (US) | 2012-08-08 | — | — | EP | disclosed |
| WO-2011041694-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | AMIRA PHARMACEUTICALS, INC. (US) | 2011-04-07 | — | — | WO | disclosed |