Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPAR1 | Q92633 | 5/20 | 0.48 |
| ▸ | FFAR1 | O14842 | 5/20 | 0.47 |
| ▸ | FFAR4 | Q5NUL3 | 5/20 | 0.47 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.40 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.39 |
| ▸ | MMP2 | P08253 | 2/20 | 0.39 |
| ▸ | MMP9 | P14780 | 2/20 | 0.39 |
| ▸ | MMP12 | P39900 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.39 |
| ▸ | MMP1 | P03956 | 1/20 | 0.38 |
| ▸ | MMP3 | P08254 | 1/20 | 0.38 |
| ▸ | MMP8 | P22894 | 1/20 | 0.38 |
| ▸ | MMP13 | P45452 | 1/20 | 0.38 |
| ▸ | MMP14 | P50281 | 1/20 | 0.38 |
| ▸ | MMP16 | P51512 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6661 | 0.91 | FFAR1 (0.41) | LPAR1FFAR1FFAR4ALOX5HPGD | |
| SCHEMBL12783 | 0.82 | LPAR1 (0.36) | LPAR1FFAR4PTGDR2PTGS1PTGS2 | |
| SCHEMBL7121 | 0.79 | LPAR1 (0.35) | LPAR1FFAR4PTGDR2HPGDPTGS1 | |
| SCHEMBL7026 | 0.78 | AOC3 (0.37) | FFAR4ALOX5SLC6A9NPC1L3MBTL1 | |
| SCHEMBL7666 | 0.78 | ABCC3 (0.44) | LPAR1ALOX5SLC6A9NPC1AOC3 | |
| SCHEMBL14822 | 0.77 | LPAR1 (0.49) | LPAR1FFAR1FFAR4PTGDR2MMP2 | |
| SCHEMBL4216332 | 0.74 | MMP2 (0.62) | LPAR1FFAR1FFAR4PTGDR2MMP2 | |
| SCHEMBL7396 | 0.73 | CYP4F2 (0.35) | HPGDL3MBTL1 | |
| SCHEMBL17260556 | 0.73 | LPAR1 (0.47) | LPAR1FFAR1FFAR4PTGDR2MMP2 | |
| SCHEMBL6613 | 0.73 | FFAR4 (0.35) | LPAR1FFAR4ALOX5SLC6A9NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011041694-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | AMIRA PHARMACEUTICALS, INC. (US) | 2011-04-07 | — | — | WO | claimed |
| EP-2483252-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | Amira Pharmaceuticals, Inc. (US) | 2012-08-08 | — | — | EP | disclosed |
| WO-2011041694-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | AMIRA PHARMACEUTICALS, INC. (US) | 2011-04-07 | — | — | WO | disclosed |