Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 6/20 | 0.46 |
| ▸ | PREP | P48147 | 4/20 | 0.46 |
| ▸ | FAP | Q12884 | 2/20 | 0.46 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.46 |
| ▸ | DPP9 | Q86TI2 | 2/20 | 0.46 |
| ▸ | VNN1 | O95497 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30874909 | 0.77 | VNN1 (0.47) | DPP4DPP9VNN1 | |
| SCHEMBL19692655 | 0.73 | DPP4 (0.51) | DPP4PREPFAP | |
| SCHEMBL15129897 | 0.73 | DPP4 (0.51) | DPP4PREPFAP | |
| SCHEMBL25718613 | 0.73 | SMN1; SMN2 (0.58) | KDM4ERAB9ASMN1; SMN2 | |
| SCHEMBL30874886 | 0.73 | VNN1 (0.43) | DPP4VNN1SMN1; SMN2 | |
| SCHEMBL12674524 | 0.72 | DPP4 (0.43) | DPP4PREPFAPDPP8DPP9 | |
| SCHEMBL6887774 | 0.72 | DPP4 (0.55) | DPP4PREPFAPDPP8DPP9 | |
| SCHEMBL17188719 | 0.72 | DPP4 (0.47) | DPP4PREPFAP | |
| SCHEMBL6519298 | 0.72 | DPP4 (0.47) | DPP4PREPFAPDPP8DPP9 | |
| SCHEMBL30493625 | 0.72 | DPP4 (0.60) | DPP4PREPFAP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2305697-A2 | Macrocyclic inhibitors of Hepatitis C virus replication | Intermune, Inc. (US) | 2011-04-06 | — | — | EP | disclosed |
| EP-2305698-A2 | Macrocyclic inhibitors of Hepatitis C virus replication | Intermune, Inc. (US) | 2011-04-06 | — | — | EP | disclosed |