Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAS2R14 | Q9NYV8 | 18/20 | 1.00 |
| ▸ | MEN1 | O00255 | 2/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 2/20 | 1.00 |
| ▸ | CXCR3 | P49682 | 2/20 | 0.83 |
| ▸ | PTGES | O14684 | 2/20 | 0.79 |
| ▸ | TAS2R8 | Q9NYW2 | 1/20 | 0.77 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1278788 | 0.98 | TAS2R14 (0.97) | TAS2R14MEN1KMT2ACXCR3PTGES | |
| SCHEMBL1279120 | 0.93 | TAS2R14 (1.00) | TAS2R14MEN1KMT2ACXCR3PTGES | |
| SCHEMBL1615782 | 0.91 | TAS2R14 (0.83) | TAS2R14MEN1KMT2ACXCR3PTGES | |
| SCHEMBL1279324 | 0.91 | TAS2R14 (1.00) | TAS2R14MEN1KMT2ACXCR3PTGES | |
| SCHEMBL1169654 | 0.91 | TAS2R14 (1.00) | TAS2R14MEN1KMT2ACXCR3PTGES | |
| SCHEMBL1279281 | 0.91 | TAS2R14 (1.00) | TAS2R14MEN1KMT2ACXCR3PTGES | |
| SCHEMBL1279497 | 0.91 | TAS2R14 (1.00) | TAS2R14MEN1KMT2ACXCR3PTGES | |
| SCHEMBL1279183 | 0.91 | TAS2R14 (1.00) | TAS2R14MEN1KMT2ACXCR3PTGES | |
| SCHEMBL1168758 | 0.91 | TAS2R14 (1.00) | TAS2R14MEN1KMT2ACXCR3PTGES | |
| SCHEMBL1278774 | 0.88 | TAS2R14 (1.00) | TAS2R14MEN1KMT2ACXCR3PTGES |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 45 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9247759-B2 | Identification of human T2R receptors that respond to bitter compounds that elicit the bitter taste in compositions, and the use thereof in assays to identify compounds that inhibit (block) bitter taste in compositions and use thereof | SENOMYX, INC. (US) | 2016-02-02 | — | — | US | disclosed |
| US-9247759-B2 | Identification of human T2R receptors that respond to bitter compounds that elicit the bitter taste in compositions, and the use thereof in assays to identify compounds that inhibit (block) bitter taste in compositions and use thereof | SENOMYX, INC. (US) | 2016-02-02 | — | — | US | disclosed |
| US-9247759-B2 | Identification of human T2R receptors that respond to bitter compounds that elicit the bitter taste in compositions, and the use thereof in assays to identify compounds that inhibit (block) bitter taste in compositions and use thereof | SENOMYX, INC. (US) | 2016-02-02 | — | — | US | disclosed |
| US-20130345222-A1 | IDENTIFICATION OF HUMAN T2R RECEPTORS THAT RESPOND TO BITTER COMPOUNDS THAT ELICIT THE BITTER TASTE IN COMPOSITIONS, AND THE USE THEREOF IN ASSAYS TO IDENTIFY COMPOUNDS THAT INHIBIT (BLOCK) BITTER TASTE IN COMPOSITIONS AND USE THEREOF | FIRMENICH INCORPORATED | 2013-12-26 | — | — | US | disclosed |
| US-20130183252-A1 | COMPOUNDS THAT INHIBIT (BLOCK) BITTER TASTE IN COMPOSITION AND METHODS OF MAKING SAME | SENOMYX, INC. (US) | 2013-07-18 | — | — | US | disclosed |
| US-20130183252-A1 | COMPOUNDS THAT INHIBIT (BLOCK) BITTER TASTE IN COMPOSITION AND METHODS OF MAKING SAME | SENOMYX, INC. (US) | 2013-07-18 | — | — | US | disclosed |
| US-20130183252-A1 | COMPOUNDS THAT INHIBIT (BLOCK) BITTER TASTE IN COMPOSITION AND METHODS OF MAKING SAME | SENOMYX, INC. (US) | 2013-07-18 | — | — | US | disclosed |
| US-8445692-B2 | Compounds that inhibit (block) bitter taste in composition and use thereof | SENOMYX INC. (US) | 2013-05-21 | — | — | US | disclosed |
| US-8445692-B2 | Compounds that inhibit (block) bitter taste in composition and use thereof | SENOMYX INC. (US) | 2013-05-21 | — | — | US | disclosed |
| US-8445692-B2 | Compounds that inhibit (block) bitter taste in composition and use thereof | SENOMYX INC. (US) | 2013-05-21 | — | — | US | disclosed |
| US-20090175805-A1 | Neuraminidase Inhibitors and uses thereof | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2009-07-09 | — | — | US | disclosed |
| WO-2009025793-A2 | HUMAN T2R BITTERNESS RECEPTORS AND USES THEREOF | SENOMYX, INC. (US) | 2009-02-26 | — | — | WO | disclosed |
| WO-2009025793-A2 | HUMAN T2R BITTERNESS RECEPTORS AND USES THEREOF | SENOMYX, INC. (US) | 2009-02-26 | — | — | WO | disclosed |
| CN-1202104-C | 2-phenylpyran-4-one derivatives | ALMIRALL PRODESFARMA SA (CH) | 2005-05-18 | — | — | CN | disclosed |
| US-6518303-B2 | Selectively inhibit COX-2 in preference to COX-1 and are useful in the treatment of COX-2 mediated diseases, such as inflammation, pain, fever and asthma with fewer side effects | ALMIRALL PRODESFARMA S.A. (ES) | 2003-02-11 | — | — | US | disclosed |
| EP-1115716-B1 | 2-PHENYLPYRAN-4-ONE DERIVATIVES | ALMIRALL PRODESFARMA AG (CH) | 2003-01-02 | — | — | EP | disclosed |
| US-20020045644-A1 | 2-phenylpyran-4-one derivatives | LABORATORIES ALMIRALL, S.A. (ES) | 2002-04-18 | — | — | US | disclosed |
| CN-1324352-A | 2-phenylpyran-4-one derivatives | ALMIRALL PRODESFARMA SA (ES) | 2001-11-28 | — | — | CN | disclosed |
| EP-1115716-A1 | 2-PHENYLPYRAN-4-ONE DERIVATIVES | Almirall Prodesfarma, S.A. (ES) | 2001-07-18 | — | — | EP | disclosed |
| WO-2000018753-A1 | 2-PHENYLPYRAN-4-ONE DERIVATIVES | ALMIRALL PRODESFARMA, S.A. (ES) | 2000-04-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090175805-A1 | Neuraminidase Inhibitors and uses thereof | ENGASE, NEU1, NEU2 | TAS2R14 1385/4885MEN1 3855/4885KMT2A 1575/4885 |
| US-20130183252-A1 | COMPOUNDS THAT INHIBIT (BLOCK) BITTER TASTE IN COMPOSITION AND METHODS OF MAKING SAME | TAS2R50, TAS2R1, TAS2R5 | TAS2R14 28/4885MEN1 2135/4885KMT2A 3279/4885 |
| US-20020045644-A1 | 2-phenylpyran-4-one derivatives | NR4A1, CYP3A4, HTR4 | TAS2R14 2500/4885MEN1 4103/4885KMT2A 2357/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.