Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | TDO2 | P48775 | 3/20 | 0.38 |
| ▸ | IDO2 | Q6ZQW0 | 3/20 | 0.38 |
| ▸ | IDO1 | P14902 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | GHSR | Q92847 | 1/20 | 0.33 |
| ▸ | CXCR3 | P49682 | 2/20 | 0.33 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12789455 | 0.92 | POLB (0.40) | POLBTDO2IDO2IDO1L3MBTL1 | |
| SCHEMBL12789456 | 0.92 | POLB (0.40) | POLBTDO2IDO2IDO1L3MBTL1 | |
| SCHEMBL12789454 | 0.92 | POLB (0.40) | POLBTDO2IDO2IDO1L3MBTL1 | |
| SCHEMBL12789062 | 0.90 | POLB (0.38) | POLBTDO2IDO2IDO1L3MBTL1 | |
| SCHEMBL12788941 | 0.90 | CASR (0.38) | POLBTDO2IDO2IDO1L3MBTL1 | |
| SCHEMBL12788998 | 0.89 | POLB (0.39) | POLBTDO2IDO2IDO1L3MBTL1 | |
| SCHEMBL12846926 | 0.89 | POLB (0.39) | POLBTDO2IDO2IDO1L3MBTL1 | |
| SCHEMBL12788804 | 0.88 | POLB (0.39) | POLBTDO2IDO2IDO1L3MBTL1 | |
| SCHEMBL12789040 | 0.88 | POLB (0.39) | POLBTDO2IDO2IDO1L3MBTL1 | |
| SCHEMBL12788979 | 0.88 | POLB (0.37) | POLBTDO2IDO2IDO1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110065671-A1 | BICYCLIC HETEROCYCLE DERIVATIVES AND USE THEREOF AS GPR119 MODULATORS | MERCK SHARP & DOHME CORP. | 2011-03-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110065671-A1 | BICYCLIC HETEROCYCLE DERIVATIVES AND USE THEREOF AS GPR119 MODULATORS | GPR119, GPR39, GPR65 | POLB 4577/4885TDO2 2425/4885IDO2 1839/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.