Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.73 |
| ▸ | POLB | P06746 | 5/20 | 0.73 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.73 |
| ▸ | USP2 | O75604 | 2/20 | 0.71 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.64 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.64 |
| ▸ | HPGD | P15428 | 1/20 | 0.64 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.64 |
| ▸ | NAMPT | P43490 | 1/20 | 0.63 |
| ▸ | LMNA | P02545 | 1/20 | 0.60 |
| ▸ | CA1 | P00915 | 1/20 | 0.59 |
| ▸ | CA2 | P00918 | 1/20 | 0.59 |
| ▸ | CA9 | Q16790 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 3/20 | 0.59 |
| ▸ | MEN1 | O00255 | 2/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.59 |
| ▸ | GAA | P10253 | 3/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12792999 | 0.86 | ALDH1A1 (0.97) | ALDH1A1POLBKDM4EUSP2CYP1A2 | |
| SCHEMBL12793019 | 0.83 | ALDH1A1 (1.00) | ALDH1A1POLBKDM4EUSP2LMNA | |
| SCHEMBL7096080 | 0.82 | USP2 (0.80) | ALDH1A1POLBKDM4EUSP2LMNA | |
| SCHEMBL4554939 | 0.82 | USP2 (0.80) | ALDH1A1POLBKDM4EUSP2LMNA | |
| SCHEMBL3236916 | 0.81 | MAPT (0.80) | ALDH1A1POLBKDM4EUSP2HPGD | |
| SCHEMBL5363222 | 0.80 | KMT2A (0.59) | ALDH1A1POLBKDM4EUSP2CYP1A2 | |
| SCHEMBL12793023 | 0.78 | ALDH1A1 (0.70) | ALDH1A1POLBKDM4EUSP2HPGD | |
| SCHEMBL164751 | 0.78 | NAMPT (1.00) | ALDH1A1NAMPTMAPTMEN1KMT2A | |
| SCHEMBL423283 | 0.77 | MAPT (0.74) | ALDH1A1POLBUSP2HPGDMAPT | |
| SCHEMBL27898881 | 0.77 | ALDH1A1 (0.60) | ALDH1A1POLBKDM4EUSP2NAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2258356-B1 | CHEMICAL COMPOUNDS HAVING ANTIVIRAL ACTIVITY AGAINST DENGUE VIRUS AND OTHER FLAVIVIRUSES | CT INGENIERIA GENETICA BIOTECNOLOGIA (CU) | 2017-09-27 | — | — | EP | disclosed |
| US-8722742-B2 | Chemical compounds having antiviral activity against Dengue virus and other Flaviviruses | CENTRO DE INGENIERIA GENETICA Y BIOTECNOLOGIA (CU) | 2014-05-13 | — | — | US | disclosed |
| US-8722742-B2 | Chemical compounds having antiviral activity against Dengue virus and other Flaviviruses | CENTRO DE INGENIERIA GENETICA Y BIOTECNOLOGIA (CU) | 2014-05-13 | — | — | US | disclosed |
| US-20110065686-A1 | CHEMICAL COMPOUNDS HAVING ANTIVIRAL ACTIVITY AGAINST DENGUE VIRUS AND OTHER FLAVIVIRUSES | CENTRO DE INGENIERIA GENETICA Y BIOTECNOLOGIA (CU) | 2011-03-17 | — | — | US | disclosed |
| US-20110065686-A1 | CHEMICAL COMPOUNDS HAVING ANTIVIRAL ACTIVITY AGAINST DENGUE VIRUS AND OTHER FLAVIVIRUSES | CENTRO DE INGENIERIA GENETICA Y BIOTECNOLOGIA (CU) | 2011-03-17 | — | — | US | disclosed |
| EP-2258356-A2 | CHEMICAL COMPOUNDS HAVING ANTIVIRAL ACTIVITY AGAINST DENGUE VIRUS AND OTHER FLAVIVIRUSES | Centro De Ingenieria Genetica Y Biotecnologia (CU) | 2010-12-08 | — | — | EP | disclosed |
| WO-2009106019-A2 | CHEMICAL COMPOUNDS HAVING ANTIVIRAL ACTIVITY AGAINST DENGUE VIRUS AND OTHER FLAVIVIRUSES | CENTRO DE INGENIERIA GENETICA Y BIOTECNOLOGIA (CU) | 2009-09-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110065686-A1 | CHEMICAL COMPOUNDS HAVING ANTIVIRAL ACTIVITY AGAINST DENGUE VIRUS AND OTHER FLAVIVIRUSES | MAVS, EIF2AK2, ZC3HAV1 | ALDH1A1 1589/4885POLB 1092/4885KDM4E 1167/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.