Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 1/20 | 0.80 |
| ▸ | MAPT | P10636 | 2/20 | 0.77 |
| ▸ | POLB | P06746 | 3/20 | 0.71 |
| ▸ | PKM | P14618 | 1/20 | 0.70 |
| ▸ | MEN1 | O00255 | 3/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.66 |
| ▸ | GAA | P10253 | 3/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.61 |
| ▸ | HTT | P42858 | 1/20 | 0.61 |
| ▸ | LMNA | P02545 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7096080 | 1.00 | USP2 (0.80) | USP2MAPTPOLBPKMMEN1 | |
| SCHEMBL3236916 | 0.98 | MAPT (0.80) | USP2MAPTPOLBPKMMEN1 | |
| SCHEMBL423283 | 0.94 | MAPT (0.74) | USP2MAPTPOLBPKMMEN1 | |
| SCHEMBL208150 | 0.90 | POLB (0.73) | USP2MAPTPOLBPKMMEN1 | |
| SCHEMBL1711115 | 0.90 | PKM (0.85) | USP2MAPTPOLBPKMMEN1 | |
| SCHEMBL16964845 | 0.82 | PKM (0.68) | USP2MAPTPOLBPKMMEN1 | |
| SCHEMBL12793000 | 0.82 | ALDH1A1 (0.73) | USP2MAPTPOLBMEN1KMT2A | |
| SCHEMBL20387932 | 0.82 | ALDH1A1 (0.68) | USP2MAPTPOLBMEN1KMT2A | |
| Tert-Butyl Formate SCHEMBL28108074 | 0.81 | MAPT (0.58) | USP2MAPTPOLBPKMMEN1 | |
| SCHEMBL1797016 | 0.81 | MAPT (0.69) | MAPTPOLBPKMMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2134714-A1 | TRICYCLIC ISOQUINOLINE DERIVATIVES FOR TREATMENT OF OBESITY | Biovitrum AB (publ) (SE) | 2009-12-23 | — | — | EP | disclosed |
| WO-2008110598-A1 | TRICYCLIC ISOQUINOLINE DERIVATIVES FOR TREATMENT OF OBESITY | BIOVITRUM AB (PUBL) (SE) | 2008-09-18 | — | — | WO | disclosed |