Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 3/20 | 0.52 |
| ▸ | FLT3 | P36888 | 1/20 | 0.52 |
| ▸ | PLK1 | P53350 | 3/20 | 0.50 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.50 |
| ▸ | ABL1 | P00519 | 3/20 | 0.49 |
| ▸ | BCR | P11274 | 3/20 | 0.49 |
| ▸ | SRC | P12931 | 3/20 | 0.49 |
| ▸ | CAMK2D | Q13557 | 2/20 | 0.49 |
| ▸ | CDK1 | P06493 | 1/20 | 0.48 |
| ▸ | MTOR | P42345 | 1/20 | 0.48 |
| ▸ | SMG1 | Q96Q15 | 1/20 | 0.48 |
| ▸ | PIK3CG | P48736 | 6/20 | 0.47 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.47 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.47 |
| ▸ | EGFR | P00533 | 1/20 | 0.47 |
| ▸ | PRKACA | P17612 | 1/20 | 0.47 |
| ▸ | PRKACG | P22612 | 1/20 | 0.47 |
| ▸ | PRKACB | P22694 | 1/20 | 0.47 |
| ▸ | JAK3 | P52333 | 2/20 | 0.47 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14254230 | 0.84 | CAMK2D (0.59) | JAK2FLT3PLK1ABL1BCR | |
| SCHEMBL14254277 | 0.83 | CAMK2D (0.71) | JAK2FLT3PLK1CDK5ABL1 | |
| SCHEMBL12801690 | 0.83 | PIK3CG (0.54) | JAK2FLT3PLK1CDK5ABL1 | |
| SCHEMBL14254228 | 0.83 | PIK3CG (0.71) | JAK2FLT3PLK1CDK5ABL1 | |
| SCHEMBL7467043 | 0.80 | ABL1 (0.67) | JAK2CDK5ABL1BCRSRC | |
| SCHEMBL12801692 | 0.80 | PLK1 (0.51) | JAK2FLT3PLK1CDK5ABL1 | |
| SCHEMBL14254278 | 0.79 | SRC (0.55) | JAK2FLT3PLK1CDK5ABL1 | |
| SCHEMBL7528647 | 0.78 | ABL1 (0.72) | ABL1BCRSRCEGFRPRKACA | |
| SCHEMBL12800930 | 0.77 | PLK1 (0.51) | JAK2FLT3PLK1ABL1BCR | |
| SCHEMBL12801101 | 0.77 | JAK2 (0.58) | JAK2FLT3PLK1CDK5PIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011046970-A1 | AMINO - PYRIMIDINE COMPOUNDS AS INHIBITORS OF TBKL AND/OR IKK EPSILON | MYREXIS, INC. (US) | 2011-04-21 | — | — | WO | disclosed |