Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 4/20 | 0.53 |
| ▸ | CDK6 | Q00534 | 3/20 | 0.53 |
| ▸ | CSF1R | P07333 | 2/20 | 0.53 |
| ▸ | CCNT1 | O60563 | 3/20 | 0.51 |
| ▸ | CDK9 | P50750 | 3/20 | 0.51 |
| ▸ | JAK2 | O60674 | 3/20 | 0.51 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.50 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.50 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.50 |
| ▸ | FLT3 | P36888 | 1/20 | 0.49 |
| ▸ | IGF1R | P08069 | 1/20 | 0.48 |
| ▸ | JAK3 | P52333 | 1/20 | 0.48 |
| ▸ | TNIK | Q9UKE5 | 2/20 | 0.47 |
| ▸ | PKMYT1 | Q99640 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | PAK1 | Q13153 | 2/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.46 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12801393 | 0.84 | JAK2 (0.69) | CCNT1CDK9JAK2MAPK8MAPK9 | |
| SCHEMBL17071599 | 0.74 | BTK (0.56) | CCNT1CDK9JAK2JAK3BTK | |
| SCHEMBL13588456 | 0.74 | JAK2 (0.67) | CCNT1CDK9JAK2IGF1RJAK3 | |
| Hydrochloric Acid SCHEMBL4383810 | 0.73 | JAK2 (0.66) | CCNT1CDK9JAK2IGF1RJAK3 | |
| SCHEMBL1667577 | 0.73 | TBK1 (0.67) | JAK2 | |
| SCHEMBL12801650 | 0.73 | JAK2 (0.56) | JAK2JAK3KCNH2CDK2 | |
| SCHEMBL17071320 | 0.73 | BTK (0.70) | JAK2JAK3BTK | |
| SCHEMBL19527697 | 0.72 | SYK (0.48) | CDK4CDK6CSF1RCCNT1CDK9 | |
| SCHEMBL4558092 | 0.72 | JAK2 (0.54) | CCNT1CDK9JAK2MAPK8MAPK9 | |
| SCHEMBL19645835 | 0.72 | JAK2 (0.64) | CDK4CDK6CSF1RCCNT1CDK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011046970-A1 | AMINO - PYRIMIDINE COMPOUNDS AS INHIBITORS OF TBKL AND/OR IKK EPSILON | MYREXIS, INC. (US) | 2011-04-21 | — | — | WO | disclosed |