Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 3/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | CSF1R | P07333 | 2/20 | 0.46 |
| ▸ | CDK4 | P11802 | 2/20 | 0.46 |
| ▸ | CDK6 | Q00534 | 2/20 | 0.46 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.44 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.44 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.44 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.44 |
| ▸ | CDK9 | P50750 | 2/20 | 0.44 |
| ▸ | CDK2 | P24941 | 2/20 | 0.44 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.44 |
| ▸ | IGF1R | P08069 | 1/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | JAK1 | P23458 | 1/20 | 0.42 |
| ▸ | TYK2 | P29597 | 1/20 | 0.42 |
| ▸ | JAK3 | P52333 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2551874 | 0.85 | CSF1R (0.56) | SYKNPC1RAB9ASMN1; SMN2CSF1R | |
| SCHEMBL18995181 | 0.84 | LRRK2 (0.47) | CSF1RCDK4CDK6CDK2CCNE1 | |
| SCHEMBL15790797 | 0.81 | SYK (0.51) | SYKNPC1RAB9ASMN1; SMN2CSF1R | |
| SCHEMBL15321402 | 0.75 | SYK (0.42) | SYKNPC1RAB9ASMN1; SMN2CSF1R | |
| SCHEMBL2527694 | 0.74 | SYK (0.62) | SYKCSF1RMAPK9MAPK10MAPK8 | |
| SCHEMBL19527683 | 0.73 | SYK (0.47) | SYKNPC1RAB9ABCL6 | |
| SCHEMBL4039797 | 0.73 | SYK (0.49) | SYKNPC1RAB9ASMN1; SMN2CCNT1 | |
| SCHEMBL19527748 | 0.73 | TBK1 (0.37) | SYKNPC1RAB9ATNIK | |
| SCHEMBL12801712 | 0.72 | CDK4 (0.53) | NPC1RAB9ASMN1; SMN2CSF1RCDK4 | |
| SCHEMBL15651830 | 0.72 | MAPT (0.56) | NPC1RAB9ASMN1; SMN2MAP3K12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2833889-B1 | PROTEIN KINASE C INHIBITORS AND USES THEREOF | RIGEL PHARMACEUTICALS INC (US) | 2017-11-01 | — | — | EP | disclosed |