Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | CTSB | P07858 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | APEX1 | P27695 | 1/20 | 0.32 |
| ▸ | CASP6 | P55212 | 1/20 | 0.32 |
| ▸ | CA12 | O43570 | 1/20 | 0.31 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1399686 | 0.82 | TSHR (0.52) | TP53CYP3A4HPGDTSHRSMN1; SMN2 | |
| SCHEMBL31607581 | 0.71 | CASP6 (0.31) | CASP6 | |
| SCHEMBL5511605 | 0.69 | CA3 (0.39) | HPGDSMN1; SMN2HIF1AALOX15MAPK1 | |
| SCHEMBL15630446 | 0.69 | GPR35 (0.41) | TSHRSMN1; SMN2L3MBTL1CTSBGAA | |
| SCHEMBL1283268 | 0.67 | SMN1; SMN2 (0.57) | TP53CYP3A4HPGDTSHRSMN1; SMN2 | |
| SCHEMBL29833732 | 0.67 | SMN1; SMN2 (0.57) | TP53CYP3A4HPGDTSHRSMN1; SMN2 | |
| SCHEMBL14784427 | 0.66 | PDE10A (0.48) | TP53HPGDTSHRALOX15HSD17B10 | |
| SCHEMBL14784589 | 0.66 | CA1 (0.43) | CYP3A4HPGDTSHRSMN1; SMN2ALOX15 | |
| SCHEMBL27718719 | 0.65 | HPGD (0.55) | TP53CYP3A4HPGDTSHRSMN1; SMN2 | |
| SCHEMBL11671002 | 0.64 | GPR35 (0.55) | TP53CYP3A4HPGDTSHRSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2035417-B1 | BENZIMIDAZOLES AND THEIR USE FOR THE TREATEMNT OF DIABETES | ASTRAZENECA AB (SE) | 2011-03-02 | — | — | EP | disclosed |