Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.46 |
| ▸ | JAK1 | P23458 | 1/20 | 0.46 |
| ▸ | TACR1 | P25103 | 1/20 | 0.45 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.42 |
| ▸ | STS | P08842 | 1/20 | 0.42 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.42 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.41 |
| ▸ | RORC | P51449 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL642727 | 0.86 | JAK2 (0.54) | JAK2JAK1GPR119KDM4EALDH1A1 | |
| SCHEMBL642728 | 0.86 | JAK2 (0.54) | JAK2JAK1GPR119KDM4EALDH1A1 | |
| SCHEMBL13443092 | 0.84 | ACHE (0.54) | JAK2JAK1GPR119KDM4EALDH1A1 | |
| SCHEMBL30898905 | 0.81 | GPR119 (0.48) | JAK2JAK1GPR119KDM4EALDH1A1 | |
| SCHEMBL30368446 | 0.81 | GPR119 (0.48) | JAK2JAK1GPR119KDM4EALDH1A1 | |
| SCHEMBL26172310 | 0.81 | GPR119 (0.48) | JAK2JAK1GPR119KDM4EALDH1A1 | |
| SCHEMBL13206336 | 0.80 | GPR119 (0.48) | JAK2JAK1GPR119KDM4EALDH1A1 | |
| SCHEMBL12809090 | 0.80 | RORC (0.43) | JAK2JAK1TACR1GPR119KDM4E | |
| SCHEMBL3570582 | 0.80 | ACHE (0.61) | GPR119KDM4EALDH1A1ACHECHRM4 | |
| SCHEMBL3779080 | 0.80 | CHRM4 (0.56) | GPR119KDM4EALDH1A1ACHECHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1581518-B1 | SUBSTITUTED 1-PIPERIDIN-4-YL-4-PYRROLIDIN-3-YL-PIPERAZINE DERIVATIVES AND THEIR USE AS NEUROKININ ANTAGONISTS | JANSSEN PHARMACEUTICA NV (BE) | 2011-03-02 | — | — | EP | disclosed |
| US-7795261-B2 | Substituted 1-piperidin-4-yl-4-pyrrolidin-3-yl-piperazine derivatives and their use as neurokinin antagonists | JANSSEN PHARMACEUTICA NV (BE) | 2010-09-14 | — | — | US | disclosed |
| US-7795261-B2 | Substituted 1-piperidin-4-yl-4-pyrrolidin-3-yl-piperazine derivatives and their use as neurokinin antagonists | JANSSEN PHARMACEUTICA NV (BE) | 2010-09-14 | — | — | US | disclosed |