Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 4/20 | 0.39 |
| ▸ | HCRTR1 | O43613 | 6/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 5/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | TYK2 | P29597 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12809751 | 1.00 | HSD11B1 (0.39) | HSD11B1HCRTR1HSD17B10CHRM1KDM4E | |
| SCHEMBL12809700 | 0.87 | HSD11B1 (0.41) | HSD11B1HCRTR1HSD17B10CHRM1KDM4E | |
| SCHEMBL14412768 | 0.87 | HSD11B1 (0.41) | HSD11B1HCRTR1HSD17B10CHRM1KDM4E | |
| SCHEMBL14413253 | 0.86 | HSD11B1 (0.43) | HSD11B1HCRTR1 | |
| SCHEMBL12809781 | 0.85 | HSD11B1 (0.41) | HSD11B1HCRTR1HSD17B10CHRM1 | |
| SCHEMBL14412571 | 0.85 | HSD11B1 (0.43) | HSD11B1HCRTR1 | |
| SCHEMBL1407021 | 0.85 | HSD11B1 (0.54) | HSD11B1LMNA | |
| SCHEMBL12809780 | 0.84 | LMNA (0.36) | HSD11B1HSD17B10KDM4EALDH1A1HPGD | |
| SCHEMBL12809589 | 0.84 | HSD11B1 (0.34) | HSD11B1HSD17B10KDM4EALDH1A1HPGD | |
| SCHEMBL12809752 | 0.83 | CNR2 (0.35) | HSD11B1HSD17B10LMNATYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2295411-A1 | Pyrazoles as 11-beta-hsd-1 | F. Hoffmann-La Roche AG (CH) | 2011-03-16 | — | — | EP | disclosed |