Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.61 |
| ▸ | HPGD | P15428 | 4/20 | 0.61 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.61 |
| ▸ | GAA | P10253 | 6/20 | 0.59 |
| ▸ | GLA | P06280 | 5/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.57 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | ALDH2 | P05091 | 2/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | MAOA | P21397 | 3/20 | 0.55 |
| ▸ | MAOB | P27338 | 3/20 | 0.55 |
| ▸ | RAB9A | P51151 | 3/20 | 0.55 |
| ▸ | AR | P10275 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | CA2 | P00918 | 1/20 | 0.54 |
| ▸ | STS | P08842 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6589340 | 0.86 | MAOB (0.68) | ALDH1A1KDM4EHPGDHSD17B10GAA | |
| SCHEMBL6591353 | 0.82 | MAOB (0.70) | ALDH1A1KDM4EHPGDHSD17B10GAA | |
| SCHEMBL9192112 | 0.82 | MAOB (0.62) | ALDH1A1KDM4EHPGDHSD17B10GAA | |
| SCHEMBL24323053 | 0.79 | RAB9A (0.77) | ALDH1A1KDM4EHPGDHSD17B10GAA | |
| SCHEMBL22501611 | 0.78 | MAOB (0.68) | ALDH1A1KDM4EHPGDHSD17B10GAA | |
| SCHEMBL15842390 | 0.77 | ALDH1A1 (0.71) | ALDH1A1KDM4EHPGDHSD17B10GAA | |
| SCHEMBL12617399 | 0.77 | MAOB (0.70) | ALDH1A1KDM4EHPGDHSD17B10GAA | |
| Hymecromone Methyl Ether SCHEMBL31103478 | 0.76 | KDM4E (1.00) | ALDH1A1KDM4EHPGDHSD17B10GAA | |
| Hymecromone Methyl Ether SCHEMBL314248 | 0.76 | KDM4E (1.00) | ALDH1A1KDM4EHPGDHSD17B10GAA | |
| SCHEMBL9464272 | 0.76 | MAOB (0.70) | ALDH1A1KDM4EHPGDHSD17B10GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8338401-B2 | Coumarin-amide derivatives and its preparation, said drug composition and its use | INSTITUTE OF MATERIA MEDICA CHINESE ACADEMY OF MEDICAL SCIENCES (CN) | 2012-12-25 | — | — | US | disclosed |
| EP-2295053-A1 | Novel 2H-chromen-2-one-3-carboxamides for medical uses | THE INSTITUTE OF MATERIA MEDICA OF CHINESE ACADEMY OF MEDICAL SCIENCES (CN) | 2011-03-16 | — | — | EP | disclosed |