Hymecromone Methyl Ether

Hymecromone Methyl Ether

SCHEMBL314248

COc1ccc2c(C)cc(=O)oc2c1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 9/20 1.00
ALDH1A1 P00352 9/20 1.00
HSD17B10 Q99714 5/20 1.00
HPGD P15428 4/20 1.00
NPC1 O15118 4/20 0.72
RAB9A P51151 3/20 0.72
KMT2A Q03164 3/20 0.72
MEN1 O00255 2/20 0.72
CASP3 P42574 2/20 0.72
SENP8 Q96LD8 2/20 0.72
SENP7 Q9BQF6 2/20 0.72
SENP6 Q9GZR1 2/20 0.72
GAA P10253 5/20 0.68
GLA P06280 4/20 0.68
SMN1; SMN2 Q16637 2/20 0.67
CA2 P00918 2/20 0.66
STS P08842 1/20 0.66
POLB P06746 1/20 0.65
ALDH2 P05091 2/20 0.63
CA12 O43570 1/20 0.63

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hymecromone Methyl Ether SCHEMBL31103478 1.00 KDM4E (1.00) KDM4EALDH1A1HSD17B10HPGDNPC1
Hymecromone Methyl Ether SCHEMBL27790754 0.90 KDM4E (0.81) KDM4EALDH1A1HSD17B10HPGDNPC1
SCHEMBL7115071 0.86 ALDH1A1 (1.00) KDM4EALDH1A1HSD17B10HPGDNPC1
SCHEMBL3757479 0.85 ALDH1A1 (0.73) KDM4EALDH1A1HSD17B10HPGDNPC1
SCHEMBL16334329 0.84 NPC1 (1.00) KDM4EALDH1A1HSD17B10HPGDNPC1
SCHEMBL119380 0.84 KDM4E (0.72) KDM4EALDH1A1HSD17B10HPGDNPC1
SCHEMBL14424527 0.84 KDM4E (0.73) KDM4EALDH1A1HSD17B10HPGDNPC1
SCHEMBL28577943 0.84 KDM4E (0.72) KDM4EALDH1A1HSD17B10HPGDNPC1
SCHEMBL15842390 0.83 ALDH1A1 (0.71) KDM4EALDH1A1HSD17B10HPGDNPC1
SCHEMBL4386227 0.83 KDM4E (0.79) KDM4EALDH1A1HSD17B10HPGDNPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 242 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118084877-A Water-soluble fluorescent probe for detecting hypochlorite, and preparation method and application thereof 绵阳师范学院 2024-05-28 CN claimed
CN-115032312-B Method for simultaneously detecting multiple sensitization fragrances in mosquito-repellent product 浙江省产品质量安全科学研究院 2023-10-03 CN claimed
CN-116672289-A Leaf extract of white mustard and application thereof in preparing cosmetics 西藏藏医药大学 2023-09-01 CN claimed
CN-115364144-A Yuqing lobular Kuding tea extract and preparation method and application thereof 贵州省中国科学院天然产物化学重点实验室(贵州医科大学天然产物化学重点实验室) 2022-11-22 CN claimed
CN-115032312-A Method for simultaneously detecting multiple allergic aromatics in mosquito repellent product 浙江省产品质量安全科学研究院 2022-09-09 CN claimed
US-9127092-B2 Method for producing polydienes and polydiene copolymers with reduced cold flow BRIDGESTONE CORPORATION (JP) 2015-09-08 US claimed
US-20140187725-A1 METHOD FOR PRODUCING POLYDIENES AND POLYDIENE COPOLYMERS WITH REDUCED COLD FLOW BRIDGESTONE CORPORATION (JP) 2014-07-03 US claimed
US-20080009544-A1 Pharmaceutical Composition Useful as Acetylcholinesterase Inhibitors COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) 2008-01-10 US claimed
US-6630581-B2 Condensing the 3'-OH or 5'-OH group of a support-bound nucleoside or oligonucleotide with a monomeric nucleoside phosphoramidite having a carbonate-protected hydroxyl group; treating the intermediate provided with a deprotecting reagent AGILENT TECHNOLOGIES, INC. 2003-10-07 US claimed
WO-1994003168-A1 5 S PENEM DERIVATIVES, THEIR PREPARATION AND USE SMITHKLINE BEECHAM PLC (GB) 1994-02-17 WO claimed
EP-0360618-B1 LIGHT-SENSITIVE COMPOSITION FUJI PHOTO FILM CO., LTD. (JP) 1992-12-16 EP claimed
US-4812362-A POLYMERIC COATING ON GLASS OR SILICA GEL, CHROMATOGRAPHY BIO-AFFINITY SYSTEMS, INC. (US) 1989-03-14 US claimed
WO-1989001406-A1 SOLID PHASE N-HYDROXYSUCCINIMIDE REAGENTS AND USE OF SAME BIO-AFFINITY SYSTEMS, INC. (US) 1989-02-23 WO claimed
EP-0013910-B1 THEOPHYLLINE ANTIGENES AND ANTIBODIES, PROCESS FOR THEIR PREPARATION, THEIR USE IN THE DETERMINATION OF THEOPHYLLINE; TEST KIT AND ANTISERUM FOR THIS USE Byk Gulden Lomberg Chemische Fabrik GmbH (DE) 1982-12-08 EP claimed
US-4302438-A Antigen, antiserum and immunoassay for theophylline BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) 1981-11-24 US claimed
EP-0013910-A1 Theophylline antigenes and antibodies, process for their preparation, their use in the determination of theophylline; test kit and antiserum for this use Byk Gulden Lomberg Chemische Fabrik GmbH (DE) 1980-08-06 EP claimed
JP-60036495-A None JP disclosed
US-12630804-B2 Blood brain barrier model University of Lancashire (GB) 2026-05-19 US disclosed
US-4250053-A WITH FLUORESCENT COMPOUND MINNESOTA MINING AND MANUFACTURING COMPANY (US) 1981-02-10 US disclosed
EP-0013910-A1 Theophylline antigenes and antibodies, process for their preparation, their use in the determination of theophylline; test kit and antiserum for this use Byk Gulden Lomberg Chemische Fabrik GmbH (DE) 1980-08-06 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080009544-A1 Pharmaceutical Composition Useful as Acetylcholinesterase Inhibitors ACHE, BCHE, CHRNB1 KDM4E 1482/4885ALDH1A1 1025/4885HSD17B10 457/4885
US-12630804-B2 Blood brain barrier model PGF, FLT4, VEGFA KDM4E 2792/4885ALDH1A1 3389/4885HSD17B10 3851/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.