Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.43 |
| ▸ | ERN1 | O75460 | 1/20 | 0.41 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.39 |
| ▸ | MTOR | P42345 | 2/20 | 0.39 |
| ▸ | FYN | P06241 | 1/20 | 0.39 |
| ▸ | MAP4K1 | Q92918 | 2/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12811956 | 0.91 | SORD (0.40) | ALDH1A1PIK3CAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL12812387 | 0.87 | PIK3CD (0.43) | ALDH1A1HIF1AMEN1CYP1A2CYP3A4 | |
| SCHEMBL1443214 | 0.85 | ALDH1A1 (0.52) | PDE10AALDH1A1HIF1AMEN1LMNA | |
| SCHEMBL27882012 | 0.84 | MEN1 (0.47) | PDE10AALDH1A1HIF1AMEN1LMNA | |
| SCHEMBL27882073 | 0.84 | AR (0.52) | PDE10AALDH1A1HIF1AMEN1LMNA | |
| SCHEMBL1442713 | 0.83 | ALDH1A1 (0.61) | PDE10AALDH1A1HIF1AMEN1LMNA | |
| SCHEMBL1443046 | 0.79 | GAK (0.59) | PDE10AALDH1A1HIF1ACYP1A2CYP3A4 | |
| SCHEMBL1442890 | 0.79 | GAK (0.57) | PDE10AALDH1A1HIF1AMEN1LMNA | |
| SCHEMBL12811769 | 0.78 | TNIK (0.55) | PDE10AALDH1A1HIF1AMEN1LMNA | |
| SCHEMBL1442476 | 0.78 | TNIK (0.54) | PDE10AALDH1A1HIF1AMEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011026579-A1 | SUBSTITUTED AMINOQUINOXALINES AS TYROSINE THREONINE KINASE INHIBITORS | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2011-03-10 | — | — | WO | disclosed |