Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | CASP3 | P42574 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.38 |
| ▸ | RELA | Q04206 | 1/20 | 0.38 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.38 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.38 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22134653 | 0.76 | ALDH1A1 (0.43) | ALDH1A1NPC1PLA2G1BNFKB1CASP3 | |
| SCHEMBL21538604 | 0.75 | LMNA (0.40) | ALDH1A1LMNAHTTHPGDALOX15 | |
| SCHEMBL17118293 | 0.75 | LMNA (0.40) | ALDH1A1L3MBTL1LMNAHTTHPGD | |
| SCHEMBL20306061 | 0.75 | LMNA (0.50) | LMNAHTT | |
| SCHEMBL11443449 | 0.74 | TSHR (0.42) | ALDH1A1NPC1PLA2G1BNFKB1CASP3 | |
| SCHEMBL1029805 | 0.73 | ALDH1A1 (0.57) | ALDH1A1NPC1LMNAHPGDALOX15 | |
| SCHEMBL1028790 | 0.73 | ALDH1A1 (0.47) | ALDH1A1NPC1PLA2G1BNFKB1CASP3 | |
| SCHEMBL30624476 | 0.72 | ALDH1A1 (0.40) | ALDH1A1NPC1PLA2G1BNFKB1CASP3 | |
| SCHEMBL21666576 | 0.71 | ALDH1A1 (0.53) | ALDH1A1NPC1PLA2G1BNFKB1CASP3 | |
| SCHEMBL21316113 | 0.71 | PDE2A (0.50) | ALDH1A1NPC1PLA2G1BNFKB1CASP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1940835-B1 | PYRAZOLO[3,4-B]PYRIDINE COMPOUNDS, AND THEIR USE AS PDE4 INHIBITORS | GLAXO GROUP LTD (GB) | 2011-03-30 | — | — | EP | disclosed |