Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 7/20 | 0.55 |
| ▸ | PTGES | O14684 | 4/20 | 0.55 |
| ▸ | ALOX5 | P09917 | 4/20 | 0.55 |
| ▸ | PPARA | Q07869 | 4/20 | 0.48 |
| ▸ | FFAR1 | O14842 | 3/20 | 0.47 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.45 |
| ▸ | LTA4H | P09960 | 1/20 | 0.44 |
| ▸ | PPARD | Q03181 | 2/20 | 0.44 |
| ▸ | GPR34 | Q9UPC5 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13418347 | 0.79 | PPARG (0.54) | PPARGPTGESALOX5PPARAFFAR1 | |
| SCHEMBL10420797 | 0.78 | CTNNB1 (0.44) | PPARGPTGESALOX5PPARAFFAR1 | |
| SCHEMBL5727650 | 0.77 | FFAR1 (0.52) | PPARGPTGESALOX5PPARAFFAR1 | |
| SCHEMBL28860722 | 0.75 | FFAR1 (0.64) | PPARGPPARAFFAR1FFAR4LTA4H | |
| SCHEMBL28224291 | 0.75 | FFAR1 (0.64) | PPARGPPARAFFAR1FFAR4LTA4H | |
| SCHEMBL1862136 | 0.74 | LTA4H (0.50) | PPARGPTGESALOX5PPARAFFAR1 | |
| SCHEMBL15079872 | 0.74 | NPC1 (0.69) | FFAR1LTA4H | |
| SCHEMBL1859177 | 0.73 | CYP1A2 (0.73) | — | |
| SCHEMBL8041180 | 0.72 | PPARG (0.61) | PPARGPTGESALOX5PPARAFFAR1 | |
| SCHEMBL12494431 | 0.72 | CYP1A2 (0.66) | PPARGPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1742927-B1 | BUTANOIC ACID DERIVATIVES, PROCESSES FOR THE PREPARATION THEREOF, PHARMACEUTICAL COMPOSITIONS COMPRISING THEM, AND THERAPEUTIC APPLICATIONS THREREOF | MERCK PATENT GMBH (DE) | 2011-03-30 | — | — | EP | disclosed |