SCHEMBL12815829

SCHEMBL12815829

Cc1cc([Si](C)(C)C)cc([Si](Cl)(c2cccc(C)c2C)c2cccc(C)c2C)c1

nearest known ligand 0.33

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
RAPGEF4 Q8WZA2 1/20 0.33
CYP1A2 P05177 2/20 0.30
CYP2A6 P11509 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12816487 0.91 RAPGEF4 (0.30) RAPGEF4
SCHEMBL12814590 0.90 RAPGEF4 (0.37) RAPGEF4CYP1A2CYP2A6
SCHEMBL12817340 0.87 RAPGEF4 (0.33) RAPGEF4
SCHEMBL12817211 0.87 CYP1A2 (0.32) CYP1A2CYP2A6
SCHEMBL12817003 0.81 CYP1A2 (0.32) CYP1A2CYP2A6
SCHEMBL12814914 0.81 RAPGEF4 (0.33) RAPGEF4CYP1A2CYP2A6
SCHEMBL12816189 0.79 CYP1A2 (0.30) CYP1A2CYP2A6
SCHEMBL12815429 0.78 RAPGEF4 (0.36) RAPGEF4
SCHEMBL12816653 0.77 TSHR (0.30)
SCHEMBL12816253 0.77 ALDH1A1 (0.31) RAPGEF4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2012133929-A1 METHOD FOR PRODUCING THE TRANSITION METAL ION COMPLEX, CATALYST FOR TRIMERIZATION, AND METHOD FOR PRODUCING 1-HEXENE SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2012-10-04 WO disclosed