SCHEMBL12816487

SCHEMBL12816487

Cc1cc([Si](C)(C)C)cc([Si](Cl)(c2ccccc2)c2cccc(C)c2C)c1

nearest known ligand 0.30

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
RAPGEF4 Q8WZA2 1/20 0.30
NPC1 O15118 1/20 0.30
CASP3 P42574 1/20 0.30
RAB9A P51151 1/20 0.30
SENP8 Q96LD8 1/20 0.30
SENP7 Q9BQF6 1/20 0.30
SENP6 Q9GZR1 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12814914 0.91 RAPGEF4 (0.33) RAPGEF4NPC1CASP3RAB9ASENP8
SCHEMBL12815829 0.91 RAPGEF4 (0.33) RAPGEF4
SCHEMBL12816189 0.90 CYP1A2 (0.30)
SCHEMBL1316141 0.84 TRPA1 (0.35) NPC1RAB9A
SCHEMBL12816614 0.84 MAOA (0.31)
SCHEMBL12816500 0.83 MAPT (0.33) NPC1CASP3RAB9ASENP8SENP7
SCHEMBL12817110 0.83 MAPT (0.33) NPC1CASP3RAB9ASENP8SENP7
SCHEMBL12817340 0.82 RAPGEF4 (0.33) RAPGEF4
SCHEMBL12815593 0.82 MAPT (0.33) RAB9A
SCHEMBL12817211 0.82 CYP1A2 (0.32)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2012133929-A1 METHOD FOR PRODUCING THE TRANSITION METAL ION COMPLEX, CATALYST FOR TRIMERIZATION, AND METHOD FOR PRODUCING 1-HEXENE SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2012-10-04 WO disclosed