Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 known ✓ | P23975 | 2/20 | 0.30 |
| ▸ | SLC6A3 known ✓ | Q01959 | 2/20 | 0.30 |
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.30 |
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.30 |
| ▸ | CHRM3 known ✓ | P20309 | 1/20 | 0.30 |
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.30 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | GPR84 | Q9NQS5 | 2/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | CNR2 | P34972 | 1/20 | 0.31 |
| ▸ | ESR1 | P03372 | 2/20 | 0.30 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.30 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.30 |
| ▸ | TACR2 | P21452 | 2/20 | 0.30 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL12818125 | 0.86 | PTGS2 (0.36) | PTGS2CYP3A4GPR84TDP1L3MBTL1 | |
| Hydrochloric Acid SCHEMBL12817112 | 0.84 | PTGS2 (0.34) | PTGS2CYP3A4GPR84 | |
| Hydrochloric Acid SCHEMBL12817993 | 0.84 | PTGS2 (0.34) | PTGS2CYP3A4GPR84 | |
| Hydrochloric Acid SCHEMBL12817598 | 0.82 | PTGS2 (0.33) | PTGS2CYP3A4GPR84 | |
| Hydrochloric Acid SCHEMBL12815648 | 0.82 | PTGS2 (0.36) | PTGS2CYP3A4GPR84TDP1L3MBTL1 | |
| Hydrochloric Acid SCHEMBL12818027 | 0.81 | HSD11B1 (0.36) | PTGS2GPR84TDP1L3MBTL1CNR2 | |
| Hydrochloric Acid SCHEMBL12818170 | 0.80 | KCNH2 (0.38) | PTGS2TDP1L3MBTL1CNR2HTR2A | |
| Hydrochloric Acid SCHEMBL10319455 | 0.79 | PTGS2 (0.36) | PTGS2CYP3A4GPR84TDP1L3MBTL1 | |
| Hydrochloric Acid SCHEMBL12817079 | 0.77 | PTGS2 (0.37) | PTGS2CYP3A4GPR84TDP1L3MBTL1 | |
| Hydrochloric Acid SCHEMBL10320297 | 0.77 | PTGS2 (0.37) | PTGS2CYP3A4GPR84TDP1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012133936-A1 | CATALYST FOR PRODUCING ETHYLENE-BASED POLYMER AND METHOD FOR PRODUCING THE SAME | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2012-10-04 | — | — | WO | disclosed |