Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 1/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.35 |
| ▸ | HTR6 | P50406 | 3/20 | 0.34 |
| ▸ | SCN7A | Q01118 | 1/20 | 0.34 |
| ▸ | BRD1 | O95696 | 4/20 | 0.33 |
| ▸ | BRPF1 | P55201 | 4/20 | 0.33 |
| ▸ | BRPF3 | Q9ULD4 | 3/20 | 0.33 |
| ▸ | BRD4 | O60885 | 2/20 | 0.33 |
| ▸ | BRD9 | Q9H8M2 | 2/20 | 0.33 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
| ▸ | HTR2C | P28335 | 1/20 | 0.32 |
| ▸ | DRD3 | P35462 | 1/20 | 0.32 |
| ▸ | BRD7 | Q9NPI1 | 1/20 | 0.32 |
| ▸ | ALB | P02768 | 1/20 | 0.32 |
| ▸ | PAX8 | Q06710 | 2/20 | 0.32 |
| ▸ | ACLY | P53396 | 1/20 | 0.32 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.31 |
| ▸ | NAMPT | P43490 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12818563 | 0.85 | PGR (0.32) | NAMPT | |
| SCHEMBL12818649 | 0.82 | CYP11B1 (0.43) | CYP11B1CYP11B2HTR6HTR2AHTR2C | |
| SCHEMBL12818419 | 0.80 | HTR6 (0.40) | CYP11B1CYP11B2HTR6SCN7ABRD1 | |
| SCHEMBL12817990 | 0.80 | CCR2 (0.38) | CYP11B1CYP11B2PAX8HRH3FABP1 | |
| SCHEMBL12818325 | 0.80 | SCN7A (0.35) | CYP11B1CYP11B2HTR6SCN7ABRD1 | |
| SCHEMBL12817575 | 0.79 | CYP11B1 (0.35) | CYP11B1CYP11B2PAX8FABP1HSD11B1 | |
| SCHEMBL12818004 | 0.79 | CYP11B1 (0.35) | CYP11B1CYP11B2PAX8ACLYFABP1 | |
| SCHEMBL12818201 | 0.79 | HTR6 (0.35) | CYP11B1CYP11B2HTR6SCN7ABRD1 | |
| SCHEMBL12818200 | 0.78 | HTR6 (0.34) | CYP11B1CYP11B2HTR6SCN7ABRD1 | |
| SCHEMBL1817915 | 0.76 | CCR6 (0.45) | CYP11B1CYP11B2ACLY |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012130306-A1 | BICYCLIC 2,3-DIHYRDOBENZAZINE COMPOUNDS FOR USE IN THERAPY | ELARA PHARMACEUTICALS GMBH (DE) | 2012-10-04 | — | — | WO | claimed |
| WO-2012130306-A1 | BICYCLIC 2,3-DIHYRDOBENZAZINE COMPOUNDS FOR USE IN THERAPY | ELARA PHARMACEUTICALS GMBH (DE) | 2012-10-04 | — | — | WO | disclosed |