Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 2/20 | 0.35 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.34 |
| ▸ | MEN1 | O00255 | 5/20 | 0.34 |
| ▸ | CPT1A | P50416 | 3/20 | 0.34 |
| ▸ | CPT1B | Q92523 | 3/20 | 0.34 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 4/20 | 0.33 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12818855 | 0.86 | PGR (0.36) | PDE3BPDE3ANPC1KMT2AMEN1 | |
| SCHEMBL1817593 | 0.85 | NR1H3 (0.46) | NPC1KMT2AMEN1CPT1ACPT1B | |
| SCHEMBL12817588 | 0.84 | PDE3B (0.35) | PDE3BPDE3ANPC1KMT2AMEN1 | |
| SCHEMBL12817586 | 0.84 | PDE3B (0.40) | PDE3BPDE3AKMT2AMEN1MAPT | |
| SCHEMBL12818659 | 0.83 | PIK3CD (0.42) | PDE3BPDE3AKMT2AMEN1MAPT | |
| SCHEMBL12817574 | 0.83 | RORC (0.34) | CPT1ACPT1BNR1H3CA2 | |
| SCHEMBL12818203 | 0.83 | PDE3B (0.37) | PDE3BPDE3ANPC1KMT2AMEN1 | |
| SCHEMBL12818152 | 0.82 | MEN1 (0.38) | PDE3BPDE3ANPC1KMT2AMEN1 | |
| SCHEMBL1821637 | 0.80 | PKM (0.48) | NPC1KMT2AMEN1CYP2C9ALDH1A1 | |
| SCHEMBL1819206 | 0.79 | PKM (0.42) | PDE3BPDE3ANPC1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012130306-A1 | BICYCLIC 2,3-DIHYRDOBENZAZINE COMPOUNDS FOR USE IN THERAPY | ELARA PHARMACEUTICALS GMBH (DE) | 2012-10-04 | — | — | WO | claimed |
| WO-2012130306-A1 | BICYCLIC 2,3-DIHYRDOBENZAZINE COMPOUNDS FOR USE IN THERAPY | ELARA PHARMACEUTICALS GMBH (DE) | 2012-10-04 | — | — | WO | disclosed |