Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | PGR | P06401 | 4/20 | 0.35 |
| ▸ | CPT2 | P23786 | 2/20 | 0.33 |
| ▸ | CPT1A | P50416 | 2/20 | 0.33 |
| ▸ | CPT1B | Q92523 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.31 |
| ▸ | CACNG8 | Q8WXS5 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | HTR7 | P34969 | 1/20 | 0.31 |
| ▸ | METAP2 | P50579 | 1/20 | 0.30 |
| ▸ | BLM | P54132 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12818274 | 0.90 | GAA (0.39) | GAAATMPOLBPGRKDM4E | |
| SCHEMBL12817730 | 0.85 | GAA (0.42) | GAAATMPOLBCPT2CPT1A | |
| SCHEMBL1818355 | 0.83 | CPT2 (0.41) | PGRCPT2CPT1ACPT1B | |
| SCHEMBL12817812 | 0.83 | CYP11B1 (0.39) | PGRCPT2CPT1ACPT1BMEN1 | |
| SCHEMBL12818087 | 0.82 | CYP11B1 (0.35) | PGRCPT2CPT1ACPT1BKMT2A | |
| SCHEMBL12818298 | 0.82 | CYP11B1 (0.35) | PGRCPT2CPT1ACPT1B | |
| SCHEMBL12817972 | 0.82 | GAA (0.40) | GAAATMPOLBPGRCPT2 | |
| SCHEMBL12818846 | 0.81 | PKM (0.42) | GAAATMPOLBPGRKDM4E | |
| SCHEMBL12818332 | 0.81 | GAA (0.39) | GAAATMPOLBPGRKDM4E | |
| SCHEMBL12818417 | 0.80 | PGR (0.34) | PGRCPT2CPT1ACPT1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012130306-A1 | BICYCLIC 2,3-DIHYRDOBENZAZINE COMPOUNDS FOR USE IN THERAPY | ELARA PHARMACEUTICALS GMBH (DE) | 2012-10-04 | — | — | WO | claimed |
| WO-2012130306-A1 | BICYCLIC 2,3-DIHYRDOBENZAZINE COMPOUNDS FOR USE IN THERAPY | ELARA PHARMACEUTICALS GMBH (DE) | 2012-10-04 | — | — | WO | disclosed |