Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | PGR | P06401 | 4/20 | 0.35 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | RORC | P51449 | 4/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.34 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.34 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.34 |
| ▸ | CPT2 | P23786 | 2/20 | 0.33 |
| ▸ | CPT1A | P50416 | 2/20 | 0.33 |
| ▸ | CPT1B | Q92523 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.32 |
| ▸ | CACNG8 | Q8WXS5 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | HTR7 | P34969 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12818942 | 0.86 | GAA (0.42) | GAAATMPOLBCNR1CNR2 | |
| SCHEMBL12817717 | 0.85 | GAA (0.40) | GAAATMPOLBPGRCNR1 | |
| SCHEMBL12818258 | 0.85 | GAA (0.39) | GAAATMPOLBCNR1CNR2 | |
| SCHEMBL12817683 | 0.84 | CPT2 (0.34) | GAAATMPGRCNR1CNR2 | |
| SCHEMBL12818846 | 0.83 | PKM (0.42) | GAAATMPOLBPGRRORC | |
| SCHEMBL1819673 | 0.83 | RORC (0.49) | PGRCNR1CNR2RORCNR1I2 | |
| SCHEMBL1817520 | 0.83 | RORC (0.47) | PGRCNR1CNR2RORCNR1I2 | |
| SCHEMBL12817920 | 0.82 | CYP11B1 (0.40) | PGRCNR1CNR2RORCNR1I2 | |
| SCHEMBL12818276 | 0.82 | GAA (0.39) | GAAATMPOLBPGRKDM4E | |
| SCHEMBL12818332 | 0.82 | GAA (0.39) | GAAATMPOLBPGRKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012130306-A1 | BICYCLIC 2,3-DIHYRDOBENZAZINE COMPOUNDS FOR USE IN THERAPY | ELARA PHARMACEUTICALS GMBH (DE) | 2012-10-04 | — | — | WO | claimed |
| WO-2012130306-A1 | BICYCLIC 2,3-DIHYRDOBENZAZINE COMPOUNDS FOR USE IN THERAPY | ELARA PHARMACEUTICALS GMBH (DE) | 2012-10-04 | — | — | WO | disclosed |