Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 3/20 | 0.40 |
| ▸ | PKM | P14618 | 2/20 | 0.40 |
| ▸ | PKLR | P30613 | 1/20 | 0.40 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.38 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.37 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.37 |
| ▸ | BRD1 | O95696 | 3/20 | 0.37 |
| ▸ | BRPF1 | P55201 | 3/20 | 0.37 |
| ▸ | BRPF3 | Q9ULD4 | 3/20 | 0.37 |
| ▸ | BRD4 | O60885 | 2/20 | 0.37 |
| ▸ | BRD9 | Q9H8M2 | 2/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | DRD3 | P35462 | 1/20 | 0.37 |
| ▸ | LGMN | Q99538 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 2/20 | 0.36 |
| ▸ | BRD7 | Q9NPI1 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12818301 | 0.88 | PKM (0.38) | HTR6PKMPKLRKDM2BLGMN | |
| SCHEMBL12818475 | 0.86 | PKM (0.38) | HTR6PKMPKLRKDM2BLGMN | |
| SCHEMBL12817855 | 0.84 | KDM2B (0.37) | HTR6PKMPKLRKDM2BLGMN | |
| SCHEMBL12817860 | 0.84 | CYP11B1 (0.44) | HTR6PKMKDM2BCYP11B1CYP11B2 | |
| SCHEMBL1819499 | 0.82 | PAX8 (0.44) | HTR6PKMKDM2BCYP11B1CYP11B2 | |
| SCHEMBL12817661 | 0.82 | PKM (0.43) | PKMPKLRKDM2BCYP11B1CYP11B2 | |
| SCHEMBL12817651 | 0.82 | PKM (0.43) | PKMPKLRKDM2BTHRBLMNA | |
| SCHEMBL12818419 | 0.81 | HTR6 (0.40) | HTR6PKMPKLRKDM2BCYP11B1 | |
| SCHEMBL12818627 | 0.81 | HTR6 (0.41) | HTR6PKMPKLRKDM2BCYP11B1 | |
| SCHEMBL1819022 | 0.80 | CYP11B1 (0.44) | HTR6PKMPKLRKDM2BCYP11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012130306-A1 | BICYCLIC 2,3-DIHYRDOBENZAZINE COMPOUNDS FOR USE IN THERAPY | ELARA PHARMACEUTICALS GMBH (DE) | 2012-10-04 | — | — | WO | claimed |
| WO-2012130306-A1 | BICYCLIC 2,3-DIHYRDOBENZAZINE COMPOUNDS FOR USE IN THERAPY | ELARA PHARMACEUTICALS GMBH (DE) | 2012-10-04 | — | — | WO | disclosed |