Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.42 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 2/20 | 0.41 |
| ▸ | PKLR | P30613 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 5/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12818373 | 0.87 | SMN1; SMN2 (0.42) | LMNASMN1; SMN2HTTCYP2C9PKM | |
| SCHEMBL12818394 | 0.85 | LMNA (0.41) | LMNASMN1; SMN2HTTCYP2C9PKM | |
| SCHEMBL12818509 | 0.84 | FTO (0.44) | LMNASMN1; SMN2HTTALKBH5FTO | |
| SCHEMBL12818812 | 0.84 | CYP2C9 (0.43) | CYP2C9PKMNPC1MEN1KMT2A | |
| SCHEMBL12817846 | 0.82 | LMNA (0.43) | LMNASMN1; SMN2HTTCYP2C9PKM | |
| SCHEMBL12819198 | 0.82 | LMNA (0.41) | LMNASMN1; SMN2HTTCYP2C9PKM | |
| SCHEMBL12818318 | 0.81 | LMNA (0.42) | LMNASMN1; SMN2HTTCYP2C9PKM | |
| SCHEMBL12818380 | 0.81 | LMNA (0.42) | LMNASMN1; SMN2HTTCYP2C9PKM | |
| SCHEMBL12818817 | 0.80 | LMNA (0.40) | LMNASMN1; SMN2HTTCYP2C9PKM | |
| SCHEMBL12818708 | 0.80 | BRD4 (0.45) | LMNASMN1; SMN2HTTCYP2C9PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012130306-A1 | BICYCLIC 2,3-DIHYRDOBENZAZINE COMPOUNDS FOR USE IN THERAPY | ELARA PHARMACEUTICALS GMBH (DE) | 2012-10-04 | — | — | WO | claimed |
| WO-2012130306-A1 | BICYCLIC 2,3-DIHYRDOBENZAZINE COMPOUNDS FOR USE IN THERAPY | ELARA PHARMACEUTICALS GMBH (DE) | 2012-10-04 | — | — | WO | disclosed |