Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 6/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | PKM | P14618 | 2/20 | 0.40 |
| ▸ | PKLR | P30613 | 1/20 | 0.40 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.38 |
| ▸ | HPGD | P15428 | 5/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 4/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.38 |
| ▸ | CPT1A | P50416 | 2/20 | 0.37 |
| ▸ | CPT1B | Q92523 | 2/20 | 0.37 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12818373 | 0.88 | SMN1; SMN2 (0.42) | LMNASMN1; SMN2HTTPKMPKLR | |
| SCHEMBL12818394 | 0.87 | LMNA (0.41) | LMNASMN1; SMN2HTTPKMPKLR | |
| SCHEMBL12817802 | 0.87 | LMNA (0.42) | LMNASMN1; SMN2HTTPKMPKLR | |
| SCHEMBL1817591 | 0.86 | CYP2C9 (0.51) | LMNAPKMALDH1A1TSHRMEN1 | |
| SCHEMBL12818380 | 0.86 | LMNA (0.42) | LMNASMN1; SMN2HTTPKMPKLR | |
| SCHEMBL12818817 | 0.85 | LMNA (0.40) | LMNASMN1; SMN2HTTPKMPKLR | |
| SCHEMBL12818698 | 0.85 | CYP2C9 (0.37) | SMN1; SMN2HTTALDH1A1HPGDKDM4E | |
| SCHEMBL12818239 | 0.84 | PKM (0.41) | LMNASMN1; SMN2HTTPKMPKLR | |
| SCHEMBL12818343 | 0.84 | LMNA (0.41) | LMNASMN1; SMN2HTTPKMPKLR | |
| SCHEMBL12818498 | 0.83 | PKM (0.41) | LMNASMN1; SMN2HTTPKMPKLR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012130306-A1 | BICYCLIC 2,3-DIHYRDOBENZAZINE COMPOUNDS FOR USE IN THERAPY | ELARA PHARMACEUTICALS GMBH (DE) | 2012-10-04 | — | — | WO | claimed |
| WO-2012130306-A1 | BICYCLIC 2,3-DIHYRDOBENZAZINE COMPOUNDS FOR USE IN THERAPY | ELARA PHARMACEUTICALS GMBH (DE) | 2012-10-04 | — | — | WO | disclosed |